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Aging reshapes immune cells grown from mouse bone marrow
Lab experiments across four mouse age groups found weaker responses to inflammatory and anti-inflammatory signals, alongside varied changes in gene activity and cell…Lab experiments across four mouse age groups found weaker responses to inflammatory and anti-inflammatory signals, alongside varied changes in gene activity and cell behavior.
Preprint: animal cell studyImmune response
Who was studiedMacrophages grown from mouse bone marrow, against macrophages from younger mice
What changedOlder macrophages responded less strongly to inflammatory and anti-inflammatory signals than younger macrophages
The catchMetabolic shifts were inferred from gene activity rather than measured directly