Papers on p62/SQSTM1

50 papers2 new in 30 days

Saturday, November 7

Journal of Biochemical and Molecular ToxicologyNov 7

Empagliflozin Modulates Apoptosis and Autophagy Pathways in Lung Cancer Through Network Pharmacology and In Vitro Analysis

Figure from Journal of Biochemical and Molecular Toxicology

Experiments in human cellsEmpagliflozin

Friday, October 30

Journal of Alzheimer's DiseaseOct 30

Cerebrospinal fluid p62/SQSTM1 is associated with tau pathology, brain structural alterations, and cognitive impairment in adults without dementia

Cohort study of 557 peopleSQSTM1

Wednesday, October 7

Nature CommunicationsOct 7

Targeting a cell regulator reduced bone loss in mice

In a mouse model of osteoporosis, silencing a gene or inhibiting its protein reduced the activity of cells that break down bone.In a mouse model of osteoporosis, silencing a gene or inhibiting its protein reduced the activity of cells that break down bone.

Oxr1 is upregulated during osteoclast differentiation and osteoporosis pathogenesis.

Experiments in miceBones and joints

Sunday, October 4

InflammopharmacologyOct 4

The immunoproteasome in Alzheimer's disease: a dual regulator of tau pathology and microglial senescence

Figure from Inflammopharmacology

ReviewCellular senescence

Friday, October 2

Frontiers in PharmacologyOct 2

Melissic acid reduces senescence in human stem cells via cAMP signaling

A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular exhaustion.A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular exhaustion.

High-throughput phenotypic screening identifies melissic acid as a candidate anti-senescence compound in replicatively senescent SHED.

Experiments in human cellsInterventions

Thursday, May 28

Investigative Ophthalmology & Visual ScienceMay 28

Oxidative Stress-Induced Age-Related Bullous Keratopathy in Corneal Endothelial Cells With Lipid Droplets and Vacuoles

Experiments in mouse cellsOxidative stress and ROS signaling

Monday, January 19

Cellular OncologyJan 19

Low-dose Simvastatin protects pancreatic cancer cells by promoting mitochondrial autophagy through TFEB

Experiments in human cellsSimvastatin

Friday, January 9

Journal of Endocrinological InvestigationJan 9

Caloric restriction attenuates oxidative and inflammatory markers of aging, while compromising germinative epithelium homeostasis in the rat aged testis

Experiments in 14 ratsDietary restriction

Tuesday, January 6

Frontiers in ImmunologyJan 6

Cigarette smoke exposure triggers dendritic cell-derived exosome-mediated Th17 and Treg polarization through an autophagy- and necroptosis-associated SIRT1-dependent mechanism in vitro

Experiments in mouse cellsSirtuin signaling

Monday, October 20

Veterinary Research CommunicationsOct 20

Altered endoplasmic reticulum stress response in non-infectious neuronal cytoplasmic inclusions in the brain of an aged dog

Case reportER unfolded protein response

Saturday, June 28

Journal of Molecular NeuroscienceJun 28

Fisetin Attenuates Mutant SOD1 Aggregation in Amyotrophic Lateral Sclerosis via Nrf2-Mediated Autophagy Activation

Experiments in cellsFisetin

Friday, June 20

Aging and DiseaseJun 20

Exercise as a Metabolic Regulator: Targeting AMPK/mTOR-Autophagy Crosstalk to Counteract Sarcopenic Obesity

Tuesday, September 24

AutophagySep 24

Poly-GP accumulation due to C9orf72 loss of function induces motor neuron apoptosis through autophagy and mitophagy defects

Study in peopleInterventions

Saturday, August 24

Molecular CellAug 24

Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence

Experiments in cellsCellular senescence

Thursday, August 22

bioRxivAug 22

Histone chaperone HIRA, Promyelocytic Leukemia (PML) protein and p62/SQSTM1 coordinate to regulate inflammation during cell senescence

Preprint: experiments in cellsCellular senescence

Tuesday, July 16

FASEB JournalJul 16

Autophagy regulates age-related delayed jawbone regeneration and decreased osteoblast osteogenesis by degrading FABP3

Experiments in miceInterventions

Monday, January 15

JOR SpineJan 15

Rapamycin mitigates inflammation-mediated disc matrix homeostatic imbalance by inhibiting mTORC1 and inducing autophagy through Akt activation

Experiments in cellsmTOR inhibitors

Thursday, August 3

EMBO ReportsAug 3

ENGRAILED-1 transcription factor has a paracrine neurotrophic activity on adult spinal α-motoneurons

Experiments in miceInterventions

Thursday, March 30

International Journal of Molecular SciencesMar 30

Exploration of the Antioxidant Effect of Spermidine on the Ovary and Screening and Identification of Differentially Expressed Proteins

Experiments in miceSpermidine

Sunday, December 25

Journal of Cellular PhysiologyDec 25

p62/SQSTM1 indirectly mediates remote multipotent mesenchymal cells and rescues bone loss and bone marrow integrity in ovariectomized rats

Experiments in ratsBone loss

Friday, October 14

bioRxivOct 14

In-cell chemical crosslinking identifies hotspots for p62-IκBα interaction that underscore a critical role of p62 in limiting NF-κB activation through IκBα-stabilization

Preprint: experiments in miceSQSTM1

Sunday, April 24

LifeApr 24

P62/SQSTM1 beyond Autophagy: Physiological Role and Therapeutic Applications in Laboratory and Domestic Animals

ReviewInterventions

Friday, March 4

Frontiers in Cell and Developmental BiologyMar 4

Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in Stress and Aging

ReviewAutophagy

Saturday, September 18

Journal for Immunotherapy of CancerSep 18

Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes

Experiments in miceMetformin

Friday, August 27

Oxidative Medicine and Cellular LongevityAug 27

Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain

Experiments in miceAutophagy

Sunday, June 6

NeuropharmacologyJun 6

Parecoxib alleviates the motor behavioral decline of aged rats by ameliorating mitochondrial dysfunction in the substantia nigra via COX-2/PGE2 pathway inhibition

Experiments in ratsInterventions

Saturday, May 1

International Journal of Molecular SciencesMay 1

Inhibition of Autophagy at Different Stages by ATG5 Knockdown and Chloroquine Supplementation Enhances Consistent Human Disc Cellular Apoptosis and Senescence Induction rather than Extracellular Matrix Catabolism

Experiments in human cellsApoptosis

Friday, March 12

Biochemistry BiokhimiiaMar 12

Autophagy as a Target for the Retinoprotective Effects of the Mitochondria-Targeted Antioxidant SkQ1

Experiments in animalsInterventions

Wednesday, February 10

BMC Research NotesFeb 10

Inhibition of Ref(2)P, the Drosophila homologue of the p62/SQSTM1 gene, increases lifespan and leads to a decline in motor function

Experiments in fliesMechanisms

Friday, December 11

Molecular and Cellular EndocrinologyDec 11

C1q/TNF-related protein-9 attenuates palmitic acid-induced endothelial cell senescence via increasing autophagy

Experiments in human cellsAutophagy