p62/SQSTM1

There are 21 papers on p62/SQSTM1 in aging research: 1 observational study in people, 10 in animals, 9 in cells, 1 review.

21 papers study it29 more mention it1 finding

2 new papers in 30 daysSee all 50 papers on p62/SQSTM1

Humans1
Animals7
Model organisms3
Cells9

Associations

1

neuronal senescence

upin mice1

1 study

p62/SQSTM1 is associated with neuronal senescence in mice.
“we observed accumulation of the autophagic receptor p62/SQSTM1 in neurons of old mice, which correlated with increased neuronal senescence”
Animalsneurons
Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain
Oxidative medicine and cellular longevityAug 13, 2021

Latest

9 papers in 12 months

Investigative Ophthalmology & Visual ScienceMay 28

Oxidative Stress-Induced Age-Related Bullous Keratopathy in Corneal Endothelial Cells With Lipid Droplets and Vacuoles

Experiments in mouse cellsOxidative stress and ROS signaling

Journal of Endocrinological InvestigationJan 9

Caloric restriction attenuates oxidative and inflammatory markers of aging, while compromising germinative epithelium homeostasis in the rat aged testis

Experiments in 14 ratsDietary restriction

Journal of Molecular NeuroscienceJun 28

Fisetin Attenuates Mutant SOD1 Aggregation in Amyotrophic Lateral Sclerosis via Nrf2-Mediated Autophagy Activation

Experiments in cellsFisetin

Aging and DiseaseJun 20

Exercise as a Metabolic Regulator: Targeting AMPK/mTOR-Autophagy Crosstalk to Counteract Sarcopenic Obesity

AutophagySep 24

Poly-GP accumulation due to C9orf72 loss of function induces motor neuron apoptosis through autophagy and mitophagy defects

Study in peopleInterventions

JOR SpineJan 15

Rapamycin mitigates inflammation-mediated disc matrix homeostatic imbalance by inhibiting mTORC1 and inducing autophagy through Akt activation

Experiments in cellsmTOR inhibitors

EMBO ReportsAug 3

ENGRAILED-1 transcription factor has a paracrine neurotrophic activity on adult spinal α-motoneurons

Experiments in miceInterventions

International Journal of Molecular SciencesMar 30

Exploration of the Antioxidant Effect of Spermidine on the Ovary and Screening and Identification of Differentially Expressed Proteins

Experiments in miceSpermidine

International Journal of Molecular SciencesMay 1

Inhibition of Autophagy at Different Stages by ATG5 Knockdown and Chloroquine Supplementation Enhances Consistent Human Disc Cellular Apoptosis and Senescence Induction rather than Extracellular Matrix Catabolism

Experiments in human cellsApoptosis

Molecular and Cellular EndocrinologyDec 11

C1q/TNF-related protein-9 attenuates palmitic acid-induced endothelial cell senescence via increasing autophagy

Experiments in human cellsAutophagy

See all 50 papers on p62/SQSTM1