PNAS
Protein loss speeds age-related brain decline in mice
Genetically altered mice developed barrier leakage, weaker blood flow responses and other age-related brain changes by 10 to 12 months of age.Genetically altered mice developed barrier leakage, weaker blood flow responses and other age-related brain changes by 10 to 12 months of age.
Mouse studyMechanisms
Who was studiedMice with endothelial Klf4 deletion, against control littermates
What changedMice lacking blood-vessel KLF4 had greater blood-brain barrier leakage than control littermates at 10 to 12 months
The catchThe experiment examined KLF4 loss, not whether restoring it could prevent brain decline