bioRxiv
Progeria disrupts cells in the intestinal lining in mice
Mice carrying one copy of a progeria-linked mutation developed increased gut leakage from 30 weeks, reaching levels reported in naturally aged mice over 20 months old.Mice carrying one copy of a progeria-linked mutation developed increased gut leakage from 30 weeks, reaching levels reported in naturally aged mice over 20 months old.
Preprint: mouse studyLMNA
Who was studiedMice with progeria-linked mutations
What changedNutrient-absorbing cells in progeria mice failed to fully mature
The catchGene-expression trajectories served as a proxy for absorptive cell maturation