Skip to content
AgingResearch.News
  • HomeHome
  • SearchSearch
  • AskAsk
  • FollowingFollowing
  • SavedSaved
AgingResearch.News
Aging and Disease

Context-Dependent Roles of p53 in Cellular Senescence and Fibrosis

By Asish K Ghosh, Karim Ullah, Cian O'Donnell, Rishi Arora
ReviewMechanisms
Paper
  • Cellular senescence
  • Extracellular matrix remodelling
  • p53–p21 pathway
  • Senescence-associated secretory phenotype (SASP)
  • Fibrosis
  • Fibrotic diseases

The paper

Asish K Ghosh, Karim Ullah, Cian O'Donnell, Rishi Arora

University of Chicago

Aging and Disease, 25 Aug 2026

doi.org/10.14336/ad.2026.0543PubMed 42691221

More on Cellular senescence

  • Neoplasia·2 Oct 2026

    Senescent prostate cancer cells drive stromal remodeling through TGF-beta signaling

  • bioRxiv·2 Oct 2026

    A distinct p21-driven macrophage senotype accumulates during aging and liver disease

  • Chinese Journal of Natural Medicines·2 Oct 2026

    Syringin reduces cellular senescence and pulmonary fibrosis in mice and cell models

  • Journal of Biochemical and Molecular Toxicology·7 Oct 2026

    Diesel-derived chemical triggers scarring signals in kidney cells

PrivacyTermsContact© 2026 AgingResearch.News

    News

    See all
    ER-100 glaucoma trial findings support testing higher dosesTrialsLongevity.Technology and 3 moreNew immune cell map reveals how individual immune aging trajectories divergeResearchMedical Xpress and 2 moreNewer cohorts of older Europeans show slower intrinsic capacity lossResearchThe Lancet Healthy Longevity

    Trials

    See all
    AKG and Brain Health in AgingPhase 2Registered 6 Oct 2026, University of OklahomaSafety and Preliminary Efficacy of Adipose-Derived Stem Cell Secretome in Frailty (VinVital)Phase 1Registered 2 Oct 2026, Vinmec Research Institute of Stem Cell and Gene TechnologyAI-Based Conversational Social Support for Older Adults With Heart FailureRegistered 7 Oct 2026, Chang Gung University of Science and Technology

    Trending

    See all
    Vitamin D deficiencyDiseaseSevere vitamin D deficiency is linked to higher death rates, and 1 more story this weekKetogenic dietInterventionKetogenic diet improved heart function in aged miceNicotinamide ribosideInterventionNicotinamide riboside did not improve early Parkinson diseaseTERTGeneBlood-cell telomerase delays premature aging in zebrafishPregnancyInterventionEstimated brain-age gap rises by three years in pregnancyChildhood lonelinessInterventionChildhood loneliness linked to faster frailty progression

    Topics

    See all
    Mechanisms253Interventions435Biomarkers421Populations560AI & data168Industry & policy18
    • Privacy
    • Terms
    • Contact
    • © 2026 AgingResearch.News