Multinucleation

Ovarian age measures partly shift towards host age in mice

Transplanting ovaries between younger and older mice shifted molecular age estimates in both directions, but the changes remained partial.Transplanting ovaries between younger and older mice shifted molecular age estimates in both directions, but the changes remained partial.

Limit: Changing ovarian cell composition could partly explain the shifts in molecular age estimates

Faulty debris clearance promotes ovarian fibroinflammation in mice

Using a corpus luteum tracking system in older mice, researchers linked stalled regression to persistent tissue debris, multinucleated giant cells, and localized…Using a corpus luteum tracking system in older mice, researchers linked stalled regression to persistent tissue debris, multinucleated giant cells, and localized fibroinflammation.