mtDNAcn

3 papers2 findings

Humans3

Associations

2

POLGA promoter methylation

upin humans1

1 study

POLGA promoter methylation is associated with mtDNAcn in humans.
“a positive correlation was also found between the methylation levels of the 4th CpG site in the POLGA promoter region and mtDNAcn during aging.”
Humansduring agingblood cells
Elevated mtDNA copy number in older adults is linked to methylation of mitochondrial and nuclear regulatory regions
GeroScience12 Dec 2025

More on POLGA promoter methylation

Dementia

upin humans1

1 study

mtDNAcn is associated with dementia in humans.
“blood mitochondrial DNA copy number (mtDNAcn) is associated with dementia risk”
Review13.2 yearsn = 33,852
MEDIATING PROTEINS UNDERLYING THE RELATIONSHIP BETWEEN MITOCHONDRIAL DNA COPY NUMBER AND DEMENTIA FROM TWO COHORTS
GSA 2024 abstract31 Dec 2024

More on Dementia

Latest

4 in 12 months

Communications Medicine23 Mar

Association of leukocyte mitochondrial DNA copy number and inflammation with mortality among older adults

Cohort study of 3,520 peopleBiomarkers

BMC Pregnancy and Childbirth18 Feb

Association of depressive and/or pregnancy-related anxiety symptoms in pregnancy with maternal and neonatal biologic aging

Cohort study of 751 peopleAnxiety

AAIC 2025 Abstract23 Dec

Interactive effects of telomere length, mtDNA abundance, and epigenetic age on Alzheimer’s disease endophenotypes

Cohort study of 640 peopleTelomere length

GeroScience12 Dec

Elevated mtDNA copy number in older adults is linked to methylation of mitochondrial and nuclear regulatory regions

Cross-sectional study of 119 peopleEpigenetic regulation of gene expression

medRxiv12 Aug

Integrative effects of Telomere Length, Epigenetic Age, and Mitochondrial DNA abundance in Alzheimer's Disease

Preprint: study in peopleBiomarkers

GSA 2024 Abstract1 Jan

MEDIATING PROTEINS UNDERLYING THE RELATIONSHIP BETWEEN MITOCHONDRIAL DNA COPY NUMBER AND DEMENTIA FROM TWO COHORTS

Cohort study of 33,852 peopleMitochondrion