POLGA promoter methylation

1. POLGA promoter methylation is associated with mtDNAcn in humans.

   “a positive correlation was also found between the methylation levels of the 4th CpG site in the POLGA promoter region and mtDNAcn during aging.”

   Humansduring agingblood cells

   Elevated mtDNA copy number in older adults is linked to methylation of mitochondrial and nuclear regulatory regions

   GeroScience·12 Dec 2025

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