Mitochondrial oxygen consumption rate

There are 13 papers on mitochondrial oxygen consumption rate in aging research: 1 observational study in people, 10 in animals, 2 in cells. The newest story, Nov 2, 2026: “Rodent safety archives flag compounds linked to better survival”.

Biomarker

13 papers study it10 more mention it6 findings

2 new papers in 30 daysSee all 23

“lower oxygen consumption being observed in those over 80 years of age.”
Decreased mitochondrial respiration associates with frailty in community-dwelling older adultsFrontiers in cell and developmental biology2024doi:10.3389/fcell.2024.1301433
  • Humans1
  • Animals9
  • Model organisms1
  • Cells2

Interventions

2

Spermidine

no changein mouse cells1downin mouse cells1

1 study
  1. Spermidine showed no clear effect on mitochondrial oxygen consumption rate in mouse cells.

    “whereas CD44+ CD49d+ CD8+ T cells (CD49d+ cells) were unaffected.”

    CellsCD44+ CD49d+ CD8+ T cell

    Spermidine reduces oxygen use in some immune cells from aged mice

    International immunology

  2. Spermidine decreases mitochondrial oxygen consumption rate in mouse cells.

    “exhibited a marked decrease in OCR following SPD treatment”

    CellsCD44+ CD49d- CD8+ T cell

    Spermidine reduces oxygen use in some immune cells from aged mice

    International immunology

More on Spermidine

Coenzyme Q10

upin mice1

1 study
  1. Coenzyme Q10 increases mitochondrial oxygen consumption rate in mice (aged mice).

    “The administration of exogenous water-soluble CoQ10 to aged mice via drinking water restored the mitochondrial OCR”

    Animalsaged micewater-solublemales

    Early-onset motor impairment and increased accumulation of phosphorylated α-synuclein in the motor cortex of normal aging mice are ameliorated by coenzyme Q

    Experimental gerontology

More on Coenzyme Q10

Upstream

1

Frailty

downin humans1

1 study
  1. Frailty is linked with lower mitochondrial oxygen consumption rate in humans (frail men) (p < 0.01).

    “OCR was significantly decreased in frail men (p < 0.01).”

    Humansfrail menPBMCmalesn = 58

    Decreased mitochondrial respiration associates with frailty in community-dwelling older adults

    Frontiers in cell and developmental biology

More on Frailty

Associations

2

Age

downin humans1

1 study
  1. Age is associated with mitochondrial oxygen consumption rate in humans (frail patients).

    “lower oxygen consumption being observed in those over 80 years of age.”

    Humansfrail patientsPBMC

    Decreased mitochondrial respiration associates with frailty in community-dwelling older adults

    Frontiers in cell and developmental biology

Older age

downin mice1

1 study
  1. Older age is associated with mitochondrial oxygen consumption rate in mice (aged mice compared with young mice).

    “the mitochondrial oxygen consumption rate (OCR) and coenzyme Q (CoQ) content were reduced in aged (15-month-old) male mice”

    Animalsaged mice compared with young micemales

    Early-onset motor impairment and increased accumulation of phosphorylated α-synuclein in the motor cortex of normal aging mice are ameliorated by coenzyme Q

    Experimental gerontology

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 1Mar 2026: 0Apr 2026: 0May 2026: 1Jun 2026: 0Jul 2026: 0Aug 2026: 1Sep 2026: 0Oct 2026: 1Nov 2026: 15 papers in 12 months
Aging Cell

Rodent safety archives flag compounds linked to better survival

In rodent pesticide studies, 27 of 154 substances were linked to survival increases of at least 10% at study termination.In rodent pesticide studies, 27 of 154 substances were linked to survival increases of at least 10% at study termination.

Experiments in rodentsInterventions
International Immunology

Spermidine reduces oxygen use in some immune cells from aged mice

In experiments on immune cells from aged mice, spermidine, a molecule involved in cell metabolism, reduced oxygen use in one subgroup but not another.In experiments on immune cells from aged mice, spermidine, a molecule involved in cell metabolism, reduced oxygen use in one subgroup but not another.

Animal cell studySpermidine

See all 23