Mitochondrial complex IV

1. Exercise increases mitochondrial complex IV in rats (+82%, p = 0.023).

   “Long-term physical activity increased mitochondrial complex IV activity in the cortex compared to YNG (+85%, p = 0.016) and MA-SED (+82%, p = 0.023)”

   Animalscompared to MA-SEDcortexfemales

   Effects of aging and long-term physical activity on mitochondrial physiology and redox state of the cortex and cerebellum of female rats

   Physiological reports·Dec 1, 2022

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1. Methylene blue increases mitochondrial complex IV in human cells (30%).

   “MB increases mitochondrial complex IV by 30%”

   Cellsfibroblast

   Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways

   FASEB journal : official publication of the Federation of American Societies for Experimental Biology·Oct 10, 2007

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1. Mitochondrial myopathies are associated with mitochondrial complex IV in humans (Mildly lower).

   “Mitochondrial myopathies had mildly lower Complex IV activity.”

   Humansmitochondrial myopathyproximal limb muscle

   Sarcopenia, age, atrophy, and myopathy: Mitochondrial oxidative enzyme activities

   Muscle & nerve·Oct 21, 2016

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