DAP3

Gene

1 paper4 findings

HGNCNCBI GeneTaxon

  • 1 lab in 1 country
  • Funders: Fundamental Research Funds for the Central Universities and 3 more
  • Animals1

Effects

3

Mitochondrial complex I activity

upin human cells1

1 study
  1. DAP3 increases mitochondrial complex I activity in human cells.

    “DAP3 can increase mitochondrial complex I activity in HCC cells by regulating the translation and expression of MT-ND5.”

    Cellsthrough regulation of MT-ND5 translation and expressionhepatocellular carcinoma cell

    DAP3 promotes mitochondrial activity and tumour progression in hepatocellular carcinoma by regulating MT-ND5 expression

    Cell death & disease29 Jul 2024

More on Mitochondrial complex I activity

Cellular senescence

downin human cells1

1 study
  1. DAP3 decreases cellular senescence in human cells.

    “by increasing mitochondrial respiration, inducing the epithelial-mesenchymal transition (EMT), and slowing cellular senescence.”

    Cellshepatocellular carcinomahepatocellular carcinoma cell

    DAP3 promotes mitochondrial activity and tumour progression in hepatocellular carcinoma by regulating MT-ND5 expression

    Cell death & disease29 Jul 2024

More on Cellular senescence

HCC cell proliferation, migration, and invasion

upin human cells1

1 study
  1. DAP3 increases HCC cell proliferation, migration, and invasion in human cells.

    “DAP3 can promote the proliferation, migration, and invasion of HCC cells in vitro and in vivo”

    Cellshepatocellular carcinomahepatocellular carcinoma cell

    DAP3 promotes mitochondrial activity and tumour progression in hepatocellular carcinoma by regulating MT-ND5 expression

    Cell death & disease29 Jul 2024

Associations

1

Patient survival

downin humans1

1 study
  1. DAP3 is associated with patient survival in humans.

    “the DAP3 expression in HCC samples is inversely correlated with patient survival.”

    Humanshepatocellular carcinomahepatocellular carcinoma sample

    DAP3 promotes mitochondrial activity and tumour progression in hepatocellular carcinoma by regulating MT-ND5 expression

    Cell death & disease29 Jul 2024

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