Mitochondrial calcium

3 papers1 finding

Humans1
Model organisms1
Cells1

Interventions

1

Mitoxantrone

downin worms1

1 study

Mitoxantrone decreases mitochondrial calcium in worms.
“cumulative [Ca2+]mito loading and incomplete recovery in aged pharynx, indicative of [Ca2+]mito overload, which was attenuated by inhibition of the mitochondrial Ca2+ uniporter (MCU) with mitoxantrone”
Model organismsduring repeated electric field stimulationpharyngeal muscle
Electric field stimulation in Caenorhabditis elegans as a novel approach to investigate mitochondrial Ca²⁺ homeostasis during in vivo muscle aging
Methods (San Diego, Calif.)19 Feb 2026

More on Mitoxantrone

Funding

1 grant since 2024

National Institute on AgingUS$125k

Determining the influence of metformin treatment on mitochondrial calcium flux during aerobic exercise training of healthy, aging rats
National Institute on AgingOklahoma Medical Research FoundationUS$50.7k2024–2025

Latest

11 in 12 months

Advanced Science28 Sep

Salvianolic acid A eases atherosclerosis in mice by eliminating senescent vascular cells

The compound disrupts an HSP90α complex to trigger endoplasmic reticulum stress and selectively induce apoptosis in senescent smooth muscle cells.The compound disrupts an HSP90α complex to trigger endoplasmic reticulum stress and selectively induce apoptosis in senescent smooth muscle cells.

Experiments in miceAtherosclerosis

Mechanisms of Ageing and Development19 Sep

Mitochondrial calcium sensor Tusc2 protects the aging hippocampus from proteostasis collapse in a sex-specific manner

Experiments in miceProteostasis

Nature Communications11 Sep

InsP3R signaling and actomyosin-dependent mitochondrial dynamics play essential roles in mitochondrial stress-induced longevity

Experiments in wormsMitochondrial fission and fusion

Colloids and Surfaces B, Biointerfaces29 Aug

Triple-pathway synergistic senolysis via AKAP1 silencing and calcium overload: An aptamer-functionalized DNAzyme nanoplatform for anti-pulmonary fibrosis research

Experiments in miceIdiopathic pulmonary fibrosis

Antioxidants & Redox Signaling27 Mar

Mitochondrial Dysfunction in Renal Aging: A Vicious Cycle Driving Kidney Disease Progression

ReviewMitochondrion

Methods22 Feb

Electric field stimulation in Caenorhabditis elegans as a novel approach to investigate mitochondrial Ca²⁺ homeostasis during in vivo muscle aging

Experiments in wormsCellular homeostasis

Preprint1 Jan

Age-related patterns in chemotherapy-induced peripheral neuropathy across outcome measures: A rapid review

Preprint: reviewPopulations

Aging Cell14 Dec

Small Extracellular Vesicles From Human Amniotic Membrane Mesenchymal Stem Cells Rejuvenate Senescent β Cells and Cure Age-Related Diabetes in Mice

Experiments in miceType 2 diabetes

Biochemical and Biophysical Research Communications14 Dec

Network pharmacology-based cocktail of four Ginkgo biloba compounds enhances yeast mitochondrial function and longevity

Experiments in yeastInterventions

Cellular Signalling11 Dec

ED-71 prevents glucocorticoid-induced bone loss by inhibiting type H vascular endothelial cell senescence through maintaining mitochondria-associated membrane-mediated calcium homeostasis

Experiments in animalsBones and joints