METTL3 expression

2 papers1 finding

Animals1
Cells1

Upstream

1

KMT2A

upin cells1

1 study

KMT2A increases METTL3 expression in cells.
“lysine methyltransferase 2A (KMT2A) promoted the expression of methyltransferase-like 3 (METTL3) through H3K4me3 modification”
CellsIVDD-NPCs; through H3K4me3 modificationnucleus pulposus cell
KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m⁶A modification of ATG4a to promote NPCs senescence and IVDD progression
Bone research21 Nov 2024

Latest

5 in 12 months

International Dental Journal19 May

METTL3 Regulates the Senescence of Stem Cells From the Apical Papilla by Mediating the m⁶A Modification of E2F3

Experiments in human cellsCell cycle regulation

Applied Biochemistry and Biotechnology17 Mar

Knocking Down CDKN2A Enhances the Therapeutic Effects of Metformin and Resveratrol on Diabetic Retinopathy

Experiments in ratsResveratrol

Journal of Translational Medicine20 Feb

Novel genetic variants identification and immune profiling in ataxia telangiectasia patients

Cohort study of 6 peopleImmune response

Life Sciences21 Jan

Hyperglycemia disrupts alveolar bone homeostasis by inducing stem cell senescence through Mettl3/Foxo3/Sirt1 axis in diabetic periodontitis

Experiments in miceSirtuin signalling

Aging Cell29 Dec

PRKN-Mediated Ubiquitin-Proteasome Degradation of METTL3 Promotes Cellular Senescence

Experiments in human cellsUbiquitin–proteasome system

Bone Research22 Nov

KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m⁶A modification of ATG4a to promote NPCs senescence and IVDD progression

Experiments in cellsHistone modification and chromatin remodelling

Journal of Translational Medicine24 Jun

METTL3-mediated m6A modification of SIRT1 mRNA inhibits progression of endometriosis by cellular senescence enhancing

Experiments in animalsMechanisms