3 papers2 findings
Alpha-ketoglutarate
upin mice1
Alpha-ketoglutarate improves metabolic profile in mice.
“Dietary α-ketoglutarate, replenishing TCA intermediates downstream of the PDK4 block, rescued contractile force and metabolic profiles in females.”
Animalstype II fiber-specific DNA repair-deficient mouseskeletal musclefemales
DNA damage differed by sex in mice with impaired DNA repair
Research Square6 Oct 2026Preprint
Cognitive function
mixedin humans1
Metabolic profile is associated with cognitive function in humans (300, 314, 203, and 211 features).
“300, 314, 203, and 211 were significantly correlated with change in cognitive domains of memory, reason, vocabulary, and processing speed, respectively.”
Humansplasmafive years52.1% femalesn = 165
AAIC 2025 abstract23 Dec 2025
In an experiment on cultured muscle precursor cells, electrical metabolic monitoring tracked cellular senescence and predicted whether the cells could form muscle.In an experiment on cultured muscle precursor cells, electrical metabolic monitoring tracked cellular senescence and predicted whether the cells could form muscle.
In 1,199 adults, gut microbiota composition explained more variance than age for 97% of inflammatory cytokines and 84% of tested physiological measures.In 1,199 adults, gut microbiota composition explained more variance than age for 97% of inflammatory cytokines and 84% of tested physiological measures.
The share of blood fatty acids that were polyunsaturated partly accounted for the diet–waist link: 35.6% in men and 46.5% in women.The share of blood fatty acids that were polyunsaturated partly accounted for the diet–waist link: 35.6% in men and 46.5% in women.
In 1,048 older adults, higher dietary inflammation scores were linked to greater odds of age-related muscle loss, with an odds ratio (a comparison of odds) of 1.305.In 1,048 older adults, higher dietary inflammation scores were linked to greater odds of age-related muscle loss, with an odds ratio (a comparison of odds) of 1.305.
Experiments in mice with impaired DNA repair identified a female-specific metabolic pathway; a dietary supplement restored muscle force and metabolic profiles in females.Experiments in mice with impaired DNA repair identified a female-specific metabolic pathway; a dietary supplement restored muscle force and metabolic profiles in females.
An observational study followed 337,334 UK Biobank participants for a median of approximately 13 years and linked groups based on routine health measures to differing…An observational study followed 337,334 UK Biobank participants for a median of approximately 13 years and linked groups based on routine health measures to differing disease progression.