1 paper
National Institute on AgingUS$5.6m
National Institute on AgingUniversity of Pittsburgh at PittsburghUS$125.9k2022–2027
Circulating and Brain Lipidomics, Cognition and Dementia
National Institute on AgingJohns Hopkins UniversityUS$754.8k2024–2028
National Institute on AgingUniversity of Maryland BaltimoreUS$540.4k2023–2028
National Institute on AgingUniversity of MinnesotaUS$638.4k2023–2028
In mouse midbrain and cultured human neurons, alpha-synuclein pathology led to shorter, more saturated lipid chains, an effect largely reversed in mice by intermittent…In mouse midbrain and cultured human neurons, alpha-synuclein pathology led to shorter, more saturated lipid chains, an effect largely reversed in mice by intermittent fasting.
In pigs with metabolic syndrome and coronary artery disease, semaglutide improved blood vessel widening without weight loss.In pigs with metabolic syndrome and coronary artery disease, semaglutide improved blood vessel widening without weight loss.
An analysis of human lipids, molecules used in cell membranes, linked aging to longer fatty-acid chains and lower levels of shorter lipids.An analysis of human lipids, molecules used in cell membranes, linked aging to longer fatty-acid chains and lower levels of shorter lipids.
Profiling conditioned media revealed that altered sphingolipid signaling reduces muscle stem cell pools in human cell cultures.Profiling conditioned media revealed that altered sphingolipid signaling reduces muscle stem cell pools in human cell cultures.
Multi-omics profiling in Drosophila links chromatin regulation to increased ATP, higher NAD-to-NADH ratios, and altered lipid metabolism in aged heads.Multi-omics profiling in Drosophila links chromatin regulation to increased ATP, higher NAD-to-NADH ratios, and altered lipid metabolism in aged heads.
Profiling lysosomal fractions from mouse cortex from 3 to 24 months revealed an accumulation of myelin-derived glycosphingolipids that was most pronounced in microglia.Profiling lysosomal fractions from mouse cortex from 3 to 24 months revealed an accumulation of myelin-derived glycosphingolipids that was most pronounced in microglia.
The three-dimensional cell platform maintains biological aging markers while spontaneously developing hallmark pathologies of sporadic Alzheimer disease.The three-dimensional cell platform maintains biological aging markers while spontaneously developing hallmark pathologies of sporadic Alzheimer disease.
In 23,790 older adults, higher small HDL levels tracked lower dementia risk (hazard ratios 0.89 to 0.91), while very large HDL tracked higher risk (1.10 to 1.14).In 23,790 older adults, higher small HDL levels tracked lower dementia risk (hazard ratios 0.89 to 0.91), while very large HDL tracked higher risk (1.10 to 1.14).