Metabolomics

Biomarker

1 paper

Funding

35 grants since 2022

National Institute on AgingUS$16.5mNational Cancer InstituteUS$6.4mNational Heart, Lung, and Blood InstituteUS$4.3m

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Ecotoxicology and Environmental Safety

Tributyl phosphate caused signs of liver aging in rats

An experiment in rats linked the chemical’s effects to fumarate, a substance involved in metabolism, and DNA escaping from cells’ energy-producing structures.An experiment in rats linked the chemical’s effects to fumarate, a substance involved in metabolism, and DNA escaping from cells’ energy-producing structures.

Experiments in ratsMechanisms
GeroScience

Higher brain care score is linked to younger retinal age

In 28,657 adults, higher brain care scores were linked to thicker retinal layers, and each five-unit increase was tied to a smaller retinal age gap.In 28,657 adults, higher brain care scores were linked to thicker retinal layers, and each five-unit increase was tied to a smaller retinal age gap.

Cross-sectional study of 28,657 peopleEye
medRxiv

Blood metabolites are linked to frailty in older adults

In people with an average age of 68 at risk of dementia, six of ten metabolite groups in blood plasma tracked with frailty scores.In people with an average age of 68 at risk of dementia, six of ten metabolite groups in blood plasma tracked with frailty scores.

Preprint: cohort study of 118 peopleBiomarkers
Aging Cell

Time-restricted eating slows blood vessel aging in animals

In an animal experiment, limiting daily eating hours altered gut bacteria and boosted acetic acid, easing high blood pressure and artery stiffness.In an animal experiment, limiting daily eating hours altered gut bacteria and boosted acetic acid, easing high blood pressure and artery stiffness.

Experiments in animalsDietary restriction
European Journal of Nutrition

Blood chemistry partly explained diet’s link to waist size

The share of blood fatty acids that were polyunsaturated partly accounted for the diet–waist link: 35.6% in men and 46.5% in women.The share of blood fatty acids that were polyunsaturated partly accounted for the diet–waist link: 35.6% in men and 46.5% in women.

Cohort study of 10,242 peopleMechanisms