An observational analysis of human genetic study results identified 289 lead DNA variants across 177 risk regions and prioritised candidate protein targets.An observational analysis of human genetic study results identified 289 lead DNA variants across 177 risk regions and prioritised candidate protein targets.
Genetic association study of participants in human artery disease genetic studiesMechanisms
Limit: The genetic signals concern a modelled ASCVD common factor rather than directly measured disease
Docosahexaenoic acid restored brain energy function in six- and 12-month dietary experiments in female mice carrying a human gene variant linked to Alzheimer’s disease.Docosahexaenoic acid restored brain energy function in six- and 12-month dietary experiments in female mice carrying a human gene variant linked to Alzheimer’s disease.
Experiments in 37 female ApoE3/3 and ApoE4/4 knock-in mice, against control-diet ApoE4/4 miceInterventions
Limit: Lipidomics sampled cerebellum, not cortex or hippocampus, limiting claims about brain-wide membrane rebalancing
An observational study of 182 people aged 90–100 and 306 adults aged 25–60 found weaker links between body-size measures and blood fats in the older group.An observational study of 182 people aged 90–100 and 306 adults aged 25–60 found weaker links between body-size measures and blood fats in the older group.
Cross-sectional study of 182 nonagenarians, against adults aged 25–60Biomarkers
Limit: Exceptional survivors may be metabolically unusual, limiting what age-group comparisons reveal about aging
Experiments in aged mice found that suppressing a brain stem cell enzyme restored the function of circuits that restrain nerve cell activity.Experiments in aged mice found that suppressing a brain stem cell enzyme restored the function of circuits that restrain nerve cell activity.
In mouse midbrain and cultured human neurons, alpha-synuclein pathology led to shorter, more saturated lipid chains, an effect largely reversed in mice by intermittent…In mouse midbrain and cultured human neurons, alpha-synuclein pathology led to shorter, more saturated lipid chains, an effect largely reversed in mice by intermittent fasting.