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Sterol ester

Biomarker

3 papers1 finding

  • Humans2
  • Animals1

Effects

1

Longevity

downin humans1

1 study

  1. Sterol ester decreases longevity in humans (mediated effect: -0.020, 95% CI -0.039 to -0.002, p = 0.033).

    “sterol ester (27:1/18:3) decreased genetic susceptibility to longevity (90th) by reducing ethylenediaminetetraacetic acid (EDTA) levels (mediated proportion: 13.60%; mediated effect: -0.020, 95% confidence interval [CI] -0.039 to -0.002, p = 0.033)”

    Humans

    Longevity Code: Lipidome Associations and Mediated Metabolite Effects

    Brain and behavior1 Nov 2025

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Journal of the American Heart Association

Genetic analysis links shared DNA signals to artery disease

An observational analysis of human genetic study results identified 289 lead DNA variants across 177 risk regions and prioritised candidate protein targets.An observational analysis of human genetic study results identified 289 lead DNA variants across 177 risk regions and prioritised candidate protein targets.

Genetic association study of participants in human artery disease genetic studiesMechanisms

Limit: The genetic signals concern a modelled ASCVD common factor rather than directly measured disease

Paper

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