Caloric restriction
downin rats1
Caloric restriction decreases lipid peroxides in rats.
“10-day CR suppressed RS, lipid peroxides, and COX-2 activity in aged rat kidney.”
AnimalsCompared with ad libitum feedingkidney40% of the food intake of the ad libitum subgroup10 days
Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidney
Inflammation research : official journal of the European Histamine Research Society ... [et al.]1 Mar 2009
In mice with severe mitochondrial disease, a two-drug treatment extended median lifespan from 62 days to 158 days.In mice with severe mitochondrial disease, a two-drug treatment extended median lifespan from 62 days to 158 days.
In an experiment comparing 73-week-old mice with 8-week-old mice, aging changed 85 proteins in the retina and 272 in the supporting eye tissue.In an experiment comparing 73-week-old mice with 8-week-old mice, aging changed 85 proteins in the retina and 272 in the supporting eye tissue.
In aged mice, Kazachstania pintolopesii aggravated spleen damage and immune cell ferroptosis, while astragaloside IV treatment restored immune function and iron…In aged mice, Kazachstania pintolopesii aggravated spleen damage and immune cell ferroptosis, while astragaloside IV treatment restored immune function and iron homeostasis.
In ApoE-/- mice, rapamycin reduced aortic lipid-positive area from 25.32 ± 0.98% to 12.28 ± 1.49% and increased plaque efferocytosis index from 0.36 ± 0.02 to 1.37 ±…In ApoE-/- mice, rapamycin reduced aortic lipid-positive area from 25.32 ± 0.98% to 12.28 ± 1.49% and increased plaque efferocytosis index from 0.36 ± 0.02 to 1.37 ± 0.15.
A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular exhaustion.A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular exhaustion.
Erastin and RSL3 shortened survival dose-dependently, an effect rescued by ferrostatin-1, while altering iron and lipid profiles selectively in males.Erastin and RSL3 shortened survival dose-dependently, an effect rescued by ferrostatin-1, while altering iron and lipid profiles selectively in males.
Restoring the fatty acid reversed visual decline in mice and cleared toxic oxidized lipids that otherwise trigger chronic microglial activation.Restoring the fatty acid reversed visual decline in mice and cleared toxic oxidized lipids that otherwise trigger chronic microglial activation.