Inflammatory cells: aging research evidence

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LMNA

upin mice1

1 study

LMNA increases inflammatory cells in mice.
“slight increase in adipose tissue inflammatory cells”
Animals527His LMNA transgenicadipose tissue
Cutaneous and metabolic defects associated with nuclear abnormalities in a transgenic mouse model expressing R527H lamin A mutation causing mandibuloacral dysplasia type A (MADA) syndrome
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology1 Dec 2020

Funding

3 grants since 2018

Japan Society for the Promotion of ScienceJP¥17.4m

Latest

40 in 12 months

Stem Cell Research & TherapyYesterday

Biological modification of decellularized human umbilical artery with adipose stem cells and sphingosine-1-phosphate for development of thromboresistant small caliber vascular graft

Experiments in 10 ratsThrombosis

Paper

Biochimica et Biophysica Acta General Subjects1 Oct

Chelating intracellular calcium reduces fibroblast senescence and eases lung fibrosis

Treating cells and an in vivo fibrosis model with a calcium chelator delayed senescence markers, reduced collagen buildup, and dampened inflammatory secretions.Treating cells and an in vivo fibrosis model with a calcium chelator delayed senescence markers, reduced collagen buildup, and dampened inflammatory secretions.

Experiments in animalsCellular senescence

Paper

JCI Insight29 Sep

Mild caloric restriction accelerates atherosclerosis in mice

In ApoE-deficient mice fed for six months, mild food restriction reduced weight gain by 5% but increased circulating cholesterol and accelerated plaque formation.In ApoE-deficient mice fed for six months, mild food restriction reduced weight gain by 5% but increased circulating cholesterol and accelerated plaque formation.

Experiments in miceDietary restriction

Paper

Angiogenesis26 Sep