H3K27 acetylation

3 papers2 findings

Animals2
Model organisms1

Interventions

1

Intermittent fasting

upin mice1

1 study

Intermittent fasting increases H3K27 acetylation in mice.
“recurrent IF shifted promoter regulation toward sustained H3K27 acetylation”
Animalshippocampusmonth-longfemales
Intermittent Fasting Enhances Genome Integrity and Cytoprotective Pathways via (BHB) β-Hydroxybutyrate Signaling and Chromatin Remodeling
FASEB journal : official publication of the Federation of American Societies for Experimental Biology11 Mar 2026

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Effects

1

Reactive oxygen species

downin worms1

1 study

H3K27 acetylation decreases reactive oxygen species in worms.
“stress-induced H3K27ac activates lifelong antioxidant defenses, thereby reducing reactive oxygen species (ROS) produced by stress-induced fatty acid oxidation and their accumulation during aging”
Model organismsunder hormetic nutrient stress
Hormetic fasting extends Caenorhabditis elegans lifespan via H3K27 acetylation of lipid catabolism and antioxidant genes
Cell reports8 Jun 2026

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Latest

6 in 12 months

bioRxiv18 Aug

HDAC4/5 regulate epidermal barrier function by modulating the epigenetic landscape of human keratinocytes

Preprint: experiments in human cellsCell cycle regulation

Cell Reports8 Jun

Hormetic fasting extends Caenorhabditis elegans lifespan via H3K27 acetylation of lipid catabolism and antioxidant genes

Experiments in wormsFasting

Haematologica30 Apr

SIRT3 deSUMOylation sustains hematopoietic stem cell activities under stressful conditions via the DHX58-IRF7 axis

Experiments in miceSIRT3

Molecular Cell18 Apr

FOXF1/2 establish a senescence-specific enhancer landscape to activate the pro-inflammatory senescence-associated secretory phenotype

Experiments in human cellsSenescence-associated secretory phenotype (SASP)

FASEB Journal11 Mar

Intermittent Fasting Enhances Genome Integrity and Cytoprotective Pathways via (BHB) β-Hydroxybutyrate Signaling and Chromatin Remodeling

Experiments in miceFasting

Nature Metabolism29 Jan

Lamin A/C-regulated cysteine catabolic flux modulates stem cell fate through epigenome reprogramming

Experiments in mouse cellsEpigenetic regulation of gene expression

Aging Cell15 Jul

Age-Dependent Histone Deacetylase 3 Regulation by βA3/A1-Crystallin and Inositol Hexaphosphate in Retinal Pigmented Epithelial Cells Reveals a Novel Pathway in Age-Related Macular Degeneration

Experiments in animalsEye

bioRxiv20 Nov

AZIN2-dependent polyamine metabolism determines adipocyte progenitor fate and protects against obesity and dysmetabolism

Preprint: experiments in animalsMechanisms

Neuroendocrinology4 Jan

p38 and ERK1/2-Dependent Activation of c-Jun Is Required for the Downregulation of Oxidative Stress-Induced ERα in Hypothalamic Astrocytes

Experiments in cellsMechanisms

Frontiers in Immunology14 Jun

Trained Immunity Enhances Human Monocyte Function in Aging and Sepsis

Experiments in cellsMechanisms