Semaglutide increases glucose disposal rate in humans (+38±17% (p<0.05)).
“Insulin-stimulated glucose disposal (M/I) during the high-dose insulin clamp and free-fatty-acid suppression during the low-dose insulin clamp increased by 38±17% and 65±9% (p<0.05)”
Human trialtype 2 diabetes and spinal cord injuryskeletal muscle2 mg weekly6 monthsmalesn = 5
In two prospective cohorts, each standard deviation increase in estimated glucose disposal rate was associated with a 40% lower risk of multiple cardiometabolic diseases.In two prospective cohorts, each standard deviation increase in estimated glucose disposal rate was associated with a 40% lower risk of multiple cardiometabolic diseases.
In the UK Biobank, participants with high AIP and low eGDR had a hazard ratio of 5.24 for multimorbidity compared with the low-AIP and high-eGDR group.In the UK Biobank, participants with high AIP and low eGDR had a hazard ratio of 5.24 for multimorbidity compared with the low-AIP and high-eGDR group.
Preprint: cohort study of 394,483 peopleBiomarkers