Glucose disposal rate

Biomarker

3 papers1 finding

  • Human trial3

Interventions

1

Semaglutide

upin humans1

1 study
  1. Semaglutide increases glucose disposal rate in humans (+38±17% (p<0.05)).

    “Insulin-stimulated glucose disposal (M/I) during the high-dose insulin clamp and free-fatty-acid suppression during the low-dose insulin clamp increased by 38±17% and 65±9% (p<0.05)”

    Human trialtype 2 diabetes and spinal cord injuryskeletal muscle2 mg weekly6 monthsmalesn = 5

    Semaglutide Improves Tissue-Specific Insulin Action and Reduces Liver Fat in Type 2 Diabetes with Spinal Cord Injury

    ADA Scientific Sessions 2026 abstract5 Jun 2026

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Cardiovascular Diabetology

Higher glucose disposal rate linked to lower multimorbidity risk

In two prospective cohorts, each standard deviation increase in estimated glucose disposal rate was associated with a 40% lower risk of multiple cardiometabolic diseases.In two prospective cohorts, each standard deviation increase in estimated glucose disposal rate was associated with a 40% lower risk of multiple cardiometabolic diseases.

Cohort study of 14,970 peopleCardiometabolic multimorbidity
Research Square

Metabolic markers jointly link to higher multimorbidity risk

In the UK Biobank, participants with high AIP and low eGDR had a hazard ratio of 5.24 for multimorbidity compared with the low-AIP and high-eGDR group.In the UK Biobank, participants with high AIP and low eGDR had a hazard ratio of 5.24 for multimorbidity compared with the low-AIP and high-eGDR group.

Preprint: cohort study of 394,483 peopleBiomarkers