Frequency

Papers on frequency

12,202 papers402 new in 30 days

Friday, October 9

bioRxiv

Loss of the Y chromosome barely alters tumor gene activity

Analyses of human kidney tumors, mice and cell lines showed that losing the Y chromosome produces few broad changes in gene activity across cancers.Analyses of human kidney tumors, mice and cell lines showed that losing the Y chromosome produces few broad changes in gene activity across cancers.

Loss of Y chromosome (LOY) in ccRCC and across cancer is not associated with consistent autosomal gene alterations that exceed pseudoautosomal dosage.
Preprint: cohort study in peopleMechanisms
Archives of Gerontology and Geriatrics

Depression linked to lower expected lifespan in older adults

In an observational study of 5,259 older adults in Thailand tracked for nine years, rising depressive symptoms predicted drops in how long they expected to live.In an observational study of 5,259 older adults in Thailand tracked for nine years, rising depressive symptoms predicted drops in how long they expected to live.

Cohort study of 5,259 peoplePopulations

Thursday, October 8

Journal of Alzheimer's Disease

Non-flickering light may improve some memory measures in older adults

A four-week randomized trial in 33 cognitively normal older adults found no measurable group-level differences in recordings of brain electrical activity.A four-week randomized trial in 33 cognitively normal older adults found no measurable group-level differences in recordings of brain electrical activity.

Brain cutaways in dark blue-green and gray show matching intact folds beneath broad light shapes, beside a small group of upright people.
Randomized trial in 33 peopleInterventions
JAMA Otolaryngology-- Head & Neck Surgery

Detailed hearing tests uncover genes linked to hearing loss

Analyzing hearing tests in 16,057 participants identified four candidate genes and yielded risk scores linked to deafness, whereas diagnostic codes found none.Analyzing hearing tests in 16,057 participants identified four candidate genes and yielded risk scores linked to deafness, whereas diagnostic codes found none.

Scatterplot of Genetic Architecture of Sensorineural Hearing Loss Based on International Classification of Diseases (ICD) and Pure-Tone Average (PTA) Definitions.
Genetic association study of 51,305 peopleBiomarkers
JMIR Aging

AI detects cognitive concerns in older adults with normal tests

In an observational study, 13.8% of older adults with normal cognitive test scores had memory or thinking concerns documented in their health records.In an observational study, 13.8% of older adults with normal cognitive test scores had memory or thinking concerns documented in their health records.

Cohort derivation and classification of patients with and without large language model (LLM)-identified cognitive concerns.
Cohort study of 15,750 peopleBiomarkers
Proceedings of the ACM on Interactive Mobile Wearable and Ubiquitous Technologies

Wearable patch matched artery signals with high accuracy

In experiments with 110 participants, the patch achieved 96.14% waveform similarity to medical-grade equipment without needing calibration for each person.In experiments with 110 participants, the patch achieved 96.14% waveform similarity to medical-grade equipment without needing calibration for each person.

A branching carotid artery is exposed beneath lifted neck skin carrying a dark sensor patch, surrounded by small upright, faceless people.
Trial in 110 peopleInterventions

Wednesday, October 7

European Journal of Nutrition

Carbohydrate-to-fat ratio linked to frailty in older Japanese adults

In older Japanese adults, those with the highest carbohydrate-to-fat ratio had 1.92 times the odds of frailty compared with those in the lowest quartile.In older Japanese adults, those with the highest carbohydrate-to-fat ratio had 1.92 times the odds of frailty compared with those in the lowest quartile.

Distributions of macronutrient energy percentages and the carbohydrate-to-fat energy ratio according to sex-specific protein-intake tertiles.
Cross-sectional study of 5,679 peoplePopulations