Papers on Factor 4

140 papers6 new in 30 days

Thursday, November 5

AJPM FocusNov 5

Risk factors associated with premature mortality from cardiovascular diseases in women: A scoping review

Systematic reviewCardiovascular disease

Paper

Tuesday, October 27

NutrientsOct 27

Dietary Sulfur Amino Acid Sensing and Metabolic Adaptation: From the GCN2-ATF4-FGF21 Axis to Transsulfuration and Redox Homeostasis

Integrated sulfur amino acid sensing and metabolic adaptation through the GCN2–ATF4–FGF21, transsulfuration, and SAMTOR–mTORC1 pathways.

ReviewInterventions

Paper

Human ImmunologyOct 27

IgA nephropathy: evolving pathogenic concepts and emerging targeted therapies

ReviewIgA nephropathy

Paper

Monday, October 26

ESC Congress 2026 AbstractOct 26

An immune cell molecule promotes stroke recovery in mice

In mice with induced stroke, guanosine secreted by regulatory T cells promoted meningeal lymphatic growth and fluid drainage to improve recovery.In mice with induced stroke, guanosine secreted by regulatory T cells promoted meningeal lymphatic growth and fluid drainage to improve recovery.

Mouse brains show dense lymphatic vessels with less damage versus sparse vessels with more damage, beside a mouse and immune cells releasing droplets.

Mouse studyBlood and immune system

Paper

Friday, October 16

Research SquareOct 16

The effects of Arf4 gene knockdown on Alzheimer's amyloid β deposition: Possible role in cognitive resilience

Outline of the study strategy and description of the neuropathological and clinical traits of human subjects.

Preprint: experiments in miceMechanisms

Paper

Thursday, October 8

eLifeOct 8

Periodic red light exposure eases cellular aging in mice

In aged mice, periodic red light exposure raised histone acetylation across tissues and reduced SIRT4 levels in skin cells to activate lipid metabolism.In aged mice, periodic red light exposure raised histone acetylation across tissues and reduced SIRT4 levels in skin cells to activate lipid metabolism.

Periodic red light irradiation treatment leads to increased H3K9ac and metabolism in skin tissues of a senescent mouse model.

Experiments in miceInterventions

Paper

Thursday, September 24

Nature CommunicationsSep 24

UK Biobank analysis leaves cause and effect unclear for most links

An observational genetic analysis of 458,747 UK Biobank participants recovered nearly all previously reported links, but most remained indistinguishable from effects of…An observational genetic analysis of 458,747 UK Biobank participants recovered nearly all previously reported links, but most remained indistinguishable from effects of unmeasured factors.

Causal inference performance of two Mendelian randomization (MR) approaches using CI-GWAS instrumental variable selection.

Mendelian randomization · 458,747 peopleAI & data

Paper

Thursday, September 17

Frontiers in ImmunologySep 17

Platelet factor 4 in cognitive, immune and hematopoietic aging: emerging evidence and translational challenges

Core mechanisms of PF4 in improving cognitive aging.

ReviewImmune response

Paper

Thursday, September 3

Journal of Alzheimer's DiseaseSep 3

Exploratory factor and network analysis of 43 inflammatory plasma biomarkers and cognitive performance in Black adults

Cross-sectional study of 334 peopleBiomarkers

Paper

Friday, August 28

The Journals of Gerontology, Series AAug 28

Metabolomic profiling of telomere length: associations with aging-related phenotypes and modifiable lifestyle factors in Chinese older adults

Cohort study of 5,957 peopleTelomere length

Paper

Saturday, August 15

MedicineAug 15

The role of mitochondrial fusion protein 2 in regulating ER stress in premature placental aging: A case-control study

The expression of Mfn2 and PERK in young pregnant mothers (control group) and advanced pregnant mothers (AMA group) was measured by qRT–PCR.

Case-control study in peopleER unfolded protein response

Paper

Tuesday, August 4

MenopauseAug 4

Inflammatory and immune biomarkers over midlife and future cognition in women: the SWAN HDL Ancillary Study

Cohort study of 503 peopleBiomarkers

Paper

Monday, August 3

Journal of Yeungnam Medical ScienceAug 3

Vitamin B deficiency and sarcopenia: an integrated narrative review of metabolic, inflammatory, endoplasmic reticulum stress, and myokine signaling pathways

ReviewER unfolded protein response

Paper

Wednesday, July 15

Cellular SignallingJul 15

Ubiquitin-specific protease 11 promotes tubular cell senescence via inhibiting p53 ubiquitin degradation during renal fibrosis

Experiments in miceUbiquitin–proteasome system

Paper

Thursday, June 18

PNASJun 18

Protein loss speeds age-related brain decline in mice

Genetically altered mice developed barrier leakage, weaker blood flow responses and other age-related brain changes by 10 to 12 months of age.Genetically altered mice developed barrier leakage, weaker blood flow responses and other age-related brain changes by 10 to 12 months of age.

Mouse studyMechanisms