Factor 4

There is 1 paper on Factor 4 in aging research: 1 observational study in people. The newest story, Oct 26, 2026: “An immune cell molecule promotes stroke recovery in mice”.

Biomarker

1 paper studies it139 more mention it1 finding

6 new papers in 30 daysSee all 140 papers on Factor 4

“Factor 4 (Citrulline, Ornithine, and Threonine) showed a protective effect against obesity [RR = 0.75(0.58-0.98)] in full models.”
Amino acid metabolic signatures of dynapenic obesity in older adults: a (principal component analysis) PCA-based sex-stratified analysis in the Bushehr elderly health programJournal of diabetes and metabolic disorders2025doi:10.1007/s40200-025-01746-x
  • Humans1

Associations

1

Obesity

downin humans1RR 0.75

1 study
  1. Factor 4 is linked with a lower risk of obesity in humans (RR = 0.75(0.58-0.98)).

    “Factor 4 (Citrulline, Ornithine, and Threonine) showed a protective effect against obesity [RR = 0.75(0.58-0.98)] in full models.”

    Humansserumfemalesn = 1,928

    Amino acid metabolic signatures of dynapenic obesity in older adults: a (principal component analysis) PCA-based sex-stratified analysis in the Bushehr elderly health program

    Journal of diabetes and metabolic disorders

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ESC Congress 2026 Abstract

An immune cell molecule promotes stroke recovery in mice

In mice with induced stroke, guanosine secreted by regulatory T cells promoted meningeal lymphatic growth and fluid drainage to improve recovery.In mice with induced stroke, guanosine secreted by regulatory T cells promoted meningeal lymphatic growth and fluid drainage to improve recovery.

eLife

Periodic red light exposure eases cellular aging in mice

In aged mice, periodic red light exposure raised histone acetylation across tissues and reduced SIRT4 levels in skin cells to activate lipid metabolism.In aged mice, periodic red light exposure raised histone acetylation across tissues and reduced SIRT4 levels in skin cells to activate lipid metabolism.

Experiments in miceInterventions
Nature Communications

UK Biobank analysis leaves cause and effect unclear for most links

An observational genetic analysis of 458,747 UK Biobank participants recovered nearly all previously reported links, but most remained indistinguishable from effects of…An observational genetic analysis of 458,747 UK Biobank participants recovered nearly all previously reported links, but most remained indistinguishable from effects of unmeasured factors.

Mendelian randomization · 458,747 peopleAI & data

See all 140 papers on Factor 4