Papers on Factor 1

888 papers38 new in 30 days

Saturday, November 7

AHA Scientific Sessions 2026 AbstractNov 7

Diabetes drug altered proteins linked to heart risk

Exenatide altered 527 of 4,979 measured proteins compared with placebo among 3,973 trial participants with type 2 diabetes.Exenatide altered 527 of 4,979 measured proteins compared with placebo among 3,973 trial participants with type 2 diabetes.

Blood samples contain differing mixtures of folded proteins among round blood cells, beside an open blood vessel and a small group of faceless people.

Randomized trial · 3,973 peopleType 2 diabetes

Paper

AHA Scientific Sessions 2026 AbstractNov 7

Inhibition of IGF-1 Signaling Promotes Cell Senescence and is Associated with Progression of Advanced Atherosclerosis

Experiments in pigsPI3K–AKT signaling

Paper

Friday, November 6

Blood ScienceNov 6

Single-episome delivery of BOSMK with miR-142–gated KLF4 streamlines PBMC reprogramming to iPSCs

Experiments in human cellsInterventions

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Geriatrics & Gerontology InternationalNov 6

Circulating Insulin‐Like Growth Factor‐1, Dementia, and Cognitive Subdomains: Evidence From the UK Biobank

Figure from Geriatrics & Gerontology International

Cohort study of 66,535 peopleFrontotemporal dementia

Paper

Thursday, November 5

Frontiers in EndocrinologyNov 5

D-Allulose as a Candidate Modulator of Nutrient-Responsive Signaling: The Metabo Quit Hypothesis for Healthy Aging

Accepted, not yet published: commentaryInterventions

Paper

Redox BiologyNov 5

RUNX1-BNIP3-mediated mitophagy regulates hepatocyte ferroptosis by promoting SLC25A28 degradation

Experiments in cellsFerroptosis

Paper

Wednesday, November 4

PsyArXivNov 4

Older age linked to less repetitive negative thinking

Smartphone surveys of 4,826 adults aged 18–100 supported a way to measure recurring negative thoughts and linked their fluctuations to poorer mental health.Smartphone surveys of 4,826 adults aged 18–100 supported a way to measure recurring negative thoughts and linked their fluctuations to poorer mental health.

Younger and older adults hold smartphones, with dense tangled loops above the younger group and fewer, separated loops above the older group.

Preprint: cross-sectional · 4,826 peoplePopulations

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Tuesday, November 3

BiomoleculesNov 3

The Functions and Molecular Mechanisms of SIRT7 in Mediating Fate Determinations of Stem Cells and Its Translational Applications

ReviewStem cell maintenance

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Academic Science JournalNov 3

The Klotho and disease-related with thyroid glands

ReviewKL

Paper

Monday, November 2

Journal of Physical EducationNov 2

The Role of Insulin-Like Growth Factor 1 And Irisin in Muscle Dystrophy: Effect of Age and Comparison Among Patients

Case-control study of 55 peopleMuscle

Paper

Sunday, November 1

Scientific ReportsNov 1

Cultural adaptation and validation of Eye Frailty Self-Check List for middle-aged and older adult in China

Cross-sectional study of 749 peopleBiomarkers

Paper

Friday, October 30

Frontiers in NutritionOct 30

Circadian-related rhythm robustness is associated with insulin sensitivity, insulin resistance, and triglycerides in healthy adults

Accepted, not yet published: cross-sectional study of 716 peopleTriglyceride

Paper

Frontiers in MedicineOct 30

Metformin-based glucose-lowering regimens, circulating biomarkers, and exploratory muscle outcomes in type 2 diabetes: a cross-sectional study

Cross-sectional study of 161 peopleType 2 diabetes

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Research SquareOct 30

Gene deletion reduced age-related bone loss in mice

Experiments in mice found that deleting a gene in bone-dismantling cells reduced age-related loss and porosity in bone’s dense outer shell.Experiments in mice found that deleting a gene in bone-dismantling cells reduced age-related loss and porosity in bone’s dense outer shell.

Bone cross-sections show a thick dark blue-green shell beside a thin, porous gray shell, with mice below and bone-dismantling cells along the edges.

Preprint: mouse studyBones and joints

Paper

Thursday, October 29

Cardiology DiscoveryOct 29

Empagliflozin Attenuates Left Ventricular Remodeling in Diabetic Rats: Involvement of SIRT1/PINK1 Signaling

Experiments in 8 ratsEmpagliflozin

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Food Science and Human WellnessOct 29

Urolithin A pretreatment protects against seizures through IGF-1R Tyr1166/1167 phosphorylation inhibition and enhances the antiseizure effect of valproic acid

Experiments in ratsUrolithin A

Paper

Wednesday, October 28

Brain CommunicationsOct 28

Strength training showed no clear overall effect on brain lesions

After 12 months, whole-brain lesion volume differed by minus 0.016 log-transformed cubic centimeters versus balance and tone exercises, with no clear group difference.After 12 months, whole-brain lesion volume differed by minus 0.016 log-transformed cubic centimeters versus balance and tone exercises, with no clear group difference.

Randomized trial · 73 peopleResistance training

Paper

Growth Hormone & IGF ResearchOct 28

Stanniocalcin-PAPP-A-IGFBP-IGF axis and all-cause mortality risk in aged and middle-aged adults: A systematic review

Figure from Growth Hormone & IGF Research

Systematic review of observational studiesBiomarkers

Paper

Research SquareOct 28

Aerobic Exercise Ameliorates Parkinson’s Disease by Activating FGF1/ERK1/2 Signaling and Suppressing Endoplasmic Reticulum Stress

Effects of aerobic exercise on body weight and motor behavior in PD mice.

Preprint: experiments in miceAerobic exercise

Paper

Tuesday, October 27

NutrientsOct 27

Exercise Is Associated with Skeletal Muscle Autophagy-Lysosome-Related Markers and Nrf2/ARF1 Signaling in HFD Mice

Changes in the body weight of each group of mice: (A) the weight changes of the DC and HFD groups before the intervention, * p < 0.05, ** p < 0.01 vs. DC; (B) the changes in body weight of different…

Experiments in 40 miceExercise

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International Journal of Molecular SciencesOct 27

Chronic Intermittent Hypoxia and MASLD in Obstructive Sleep Apnea: A Critical Appraisal of Mechanistic and Causal Evidence

Structure and interpretive framework of the review.

ReviewHypoxia and HIF signaling

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Chemico-biological InteractionsOct 27

Chemical exposure caused Parkinson’s-like changes in mice

Exposed mice developed dose-dependent movement and thinking problems, alongside signs of senescence, a state in which cells stop dividing, in brain immune cells.Exposed mice developed dose-dependent movement and thinking problems, alongside signs of senescence, a state in which cells stop dividing, in brain immune cells.