Enzymes

Papers on enzymes

6,700 papers162 new in 30 days

Saturday, October 24

Friday, October 23

Nature

Cold activates a chemical network that extends lifespan in worms

Experiments in worms found that boosting production of a cold-induced molecule in muscle promoted longevity and reduced protein clumping at normal or elevated…Experiments in worms found that boosting production of a cold-induced molecule in muscle promoted longevity and reduced protein clumping at normal or elevated temperatures.

Worm studyInterventions

Thursday, October 22

bioRxiv

Some preleukemic cells suppress normal neighbors in culture

About 10% of preleukemic mutant clones actively suppressed or completely eliminated competing normal cells in a laboratory culture model.About 10% of preleukemic mutant clones actively suppressed or completely eliminated competing normal cells in a laboratory culture model.

A large dark blue-green cell anchors a dense cluster of intact cells beside sparse, fragmented gray neighbors and a farther group of whole gray cells.
Preprint: animal cell studyMechanisms

Wednesday, October 21

Tuesday, October 20

Materials Today Bio

Hydrogen delivery reduced testicular deterioration in aged mice

A material injected into the scrotum stuck to tissue around the testes, sustaining local hydrogen delivery and promoting sperm production in aged mice.A material injected into the scrotum stuck to tissue around the testes, sustaining local hydrogen delivery and promoting sperm production in aged mice.

Mouse studyInterventions
Nature Communications

Muscle enzyme buildup linked to type 2 diabetes in people

A randomized trial in people with type 2 diabetes found that exercise reduced buildup of the enzyme and improved the body’s response to insulin.A randomized trial in people with type 2 diabetes found that exercise reduced buildup of the enzyme and improved the body’s response to insulin.

Miro1 accumulation is associated with insulin resistance in patients and mice with obesity and type 2 diabetes.
Cross-sectional studyType 2 diabetes
arXiv

Dementia risk model outperformed other scores in UK cohort

On a measure of distinguishing future dementia cases from noncases, the model scored 0.853 versus 0.841 for the UK Biobank Dementia Risk Prediction model.On a measure of distinguishing future dementia cases from noncases, the model scored 0.853 versus 0.841 for the UK Biobank Dementia Risk Prediction model.

Brain sections sit above groups of upright people, with a large dark blue-green brain beside a smaller gray brain with wider gaps.
Preprint: cohort · 50,041 peopleAll-cause dementia

Monday, October 19

Sunday, October 18

Saturday, October 17

Neuropharmacology

Enzyme helps regulate inflammation in lab-grown brain immune cells

Experiments in lab-grown brain immune cells found that reducing one enzyme suppressed inflammatory signals triggered by three different stimuli.Experiments in lab-grown brain immune cells found that reducing one enzyme suppressed inflammatory signals triggered by three different stimuli.

Animal cell studyInflammation