Energy balance

Biomarker

1 paper1 finding

  • Animals1

Upstream

1

C57BL/6

upin mice1

1 study
  1. C57BL/6 increases energy balance in mice.

    “The energy balance, indicated by the gain/loss in body weight per unit of food consumed, is higher in C57BL/6 than DBA/2 mice.”

    Animalscomparing C57BL/6 to DBA/2 mice

    Comparison of metabolic rate and oxidative stress between two different strains of mice with varying response to caloric restriction

    Experimental gerontology4 May 2008

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Cells

Loss of body-clock protein linked to more artery plaques in mice

Experiments linked deletion of a body-clock protein in brown fat cells to greater plaque formation in aging and young mice genetically prone to artery disease.Experiments linked deletion of a body-clock protein in brown fat cells to greater plaque formation in aging and young mice genetically prone to artery disease.

Experiments in aged male mice, one year, against controlsMechanisms

Limit: Ucp1-Cre is not PVAT-specific, so effects from other brown fat depots may confound results

Nature

Brown fat linked to less cardiovascular and psychiatric disease

An observational study of 101,243 patients at a large cancer centre linked detectable brown fat to lower prevalence of cardiovascular and psychiatric diseases.An observational study of 101,243 patients at a large cancer centre linked detectable brown fat to lower prevalence of cardiovascular and psychiatric diseases.

Case-control study of 26,302 patients at a cancer centreMechanisms

Limit: Tumour types or cancer therapies could influence the associations despite adjustment

bioRxiv

Caloric restriction delays cancer wasting in mice

In a mouse model of lung cancer, restricting food before tumour induction preserved lean mass and prolonged survival where targeting individual candidate factors failed.In a mouse model of lung cancer, restricting food before tumour induction preserved lean mass and prolonged survival where targeting individual candidate factors failed.

Preprint: experiments in miceDietary restriction
Antioxidants & Redox Signaling

Protein loss caused senescence-like changes in lab-grown neurons

Experiments in models of neurons that regulate energy balance found cell enlargement and other senescence-like changes after researchers removed or reduced selenoprotein…Experiments in models of neurons that regulate energy balance found cell enlargement and other senescence-like changes after researchers removed or reduced selenoprotein T.

Experiments in miceCellular senescence