Experiments linked deletion of a body-clock protein in brown fat cells to greater plaque formation in aging and young mice genetically prone to artery disease.Experiments linked deletion of a body-clock protein in brown fat cells to greater plaque formation in aging and young mice genetically prone to artery disease.
Experiments in aged male mice, one year, against controlsMechanisms
Limit: Ucp1-Cre is not PVAT-specific, so effects from other brown fat depots may confound results
An observational study of 101,243 patients at a large cancer centre linked detectable brown fat to lower prevalence of cardiovascular and psychiatric diseases.An observational study of 101,243 patients at a large cancer centre linked detectable brown fat to lower prevalence of cardiovascular and psychiatric diseases.
Case-control study of 26,302 patients at a cancer centreMechanisms
Limit: Tumour types or cancer therapies could influence the associations despite adjustment
In a mouse model of lung cancer, restricting food before tumour induction preserved lean mass and prolonged survival where targeting individual candidate factors failed.In a mouse model of lung cancer, restricting food before tumour induction preserved lean mass and prolonged survival where targeting individual candidate factors failed.
Experiments in models of neurons that regulate energy balance found cell enlargement and other senescence-like changes after researchers removed or reduced selenoprotein…Experiments in models of neurons that regulate energy balance found cell enlargement and other senescence-like changes after researchers removed or reduced selenoprotein T.