Dysregulation of cardioprotective protein mRNAs
1 paper1 finding
- Humans1
Interventions
1Anti-acbp monoclonal antibody
downin mice1
1 study
Anti-acbp monoclonal antibody
downin mice1
Anti-acbp monoclonal antibody decreases dysregulation of cardioprotective protein mRNAs in mice.
“In cardiomyocytes, doxorubicin caused an anti-ACBP-reversible dysregulation of mRNAs coding for cardioprotective proteins involved in autophagy, fatty acid oxidation, mitochondrial homeostasis, and oxidative phosphorylation.”
Animalsdoxorubicin exposurecardiomyocyte
Acyl-CoA-binding protein as a driver of pathological aging
Proceedings of the National Academy of Sciences of the United States of America7 Jul 2025