Cumulative incidence rate

1. Cumulative incidence rate is associated with GFAP in humans.

   “GFAP (B=390.64;; 95% CI[209.19,572.09];p<0.0001)”

   Humansplasman = 92

   Age‐anchored genetic risk for Alzheimer's disease is associated with markers of cerebrovascular disease, inflammation, and neurodegeneration in older adults without dementia

   AAIC 2025 abstract·9 Jan 2026

2. Cumulative incidence rate is associated with GFAP in humans.

   “GFAP (B=390.64;; 95% CI[209.19,572.09]; p <0.0001)”

   Humanscognitively unimpairedplasman = 92

   Age‐anchored genetic risk for Alzheimer’s disease is associated with markers of cerebrovascular disease, inflammation, and neurodegeneration in older adults without dementia

   AAIC 2025 abstract·23 Dec 2025

More on GFAP

1. Cumulative incidence rate is associated with NfL in humans.

   “NfL (B=66.68; 95% CI[32.37,101.01];p<0.001)”

   Humansplasman = 92

   Age‐anchored genetic risk for Alzheimer's disease is associated with markers of cerebrovascular disease, inflammation, and neurodegeneration in older adults without dementia

   AAIC 2025 abstract·9 Jan 2026

2. Cumulative incidence rate is associated with NfL in humans.

   “NfL (B=66.68; 95% CI[32.37,101.01]; p <0.001)”

   Humanscognitively unimpairedplasman = 92

   Age‐anchored genetic risk for Alzheimer’s disease is associated with markers of cerebrovascular disease, inflammation, and neurodegeneration in older adults without dementia

   AAIC 2025 abstract·23 Dec 2025

More on NfL

1. Cumulative incidence rate is associated with white matter hyperintensities in humans (B=4.29, 95% CI 3.14–5.44).

   “Higher CIR scores were associated with greater WMH volume (B=4.29; CI[3.14,5.44];p<0.0001)”

   Humansn = 601

   Age‐anchored genetic risk for Alzheimer's disease is associated with markers of cerebrovascular disease, inflammation, and neurodegeneration in older adults without dementia

   AAIC 2025 abstract·9 Jan 2026

2. Cumulative incidence rate is associated with white matter hyperintensities in humans (B=4.29, 95% CI 3.14–5.44, p < 0.0001).

   “Higher CIR scores were associated with greater WMH volume (B=4.29; CI[3.14,5.44]; p <0.0001)”

   Humanscognitively unimpairedbrainn = 601

   Age‐anchored genetic risk for Alzheimer’s disease is associated with markers of cerebrovascular disease, inflammation, and neurodegeneration in older adults without dementia

   AAIC 2025 abstract·23 Dec 2025

More on White matter hyperintensities

1. Cumulative incidence rate is associated with cognitive function in humans (B=-1.946, 95% CI -2.92 to -0.98).

   “Higher CIR were associated with lower executive function (B=‐1.946; CI[‐2.92,‐0.98]; p <0.0001)”

   Humansn = 601

   Age‐anchored genetic risk for Alzheimer's disease is associated with markers of cerebrovascular disease, inflammation, and neurodegeneration in older adults without dementia

   AAIC 2025 abstract·9 Jan 2026

1. Cumulative incidence rate is associated with memory in humans (B=-2.947, 95% CI -4.03 to -1.87, p < 0.0001).

   “memory (B=‐2.947; CI[‐4.03,‐1.87]; p <0.0001)”

   Humanscognitively unimpairedn = 601

   Age‐anchored genetic risk for Alzheimer’s disease is associated with markers of cerebrovascular disease, inflammation, and neurodegeneration in older adults without dementia

   AAIC 2025 abstract·23 Dec 2025