Memory
Biomarker4 papers2 findings
- Humans4
Associations
2Mortality
downin humans1HR 0.8
1 study
Mortality
downin humans1HR 0.8
Memory lowers the risk of mortality in humans (HR 0.80, [0.71, 0.91]).
Humansper 1-SD increasemedian of 11.3 yearsn = 4,561
Associations of domain-specific cognitive function with all-cause mortality over 11 years: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study · Archives of gerontology and geriatrics · 19 Aug 2026
APOE
downin humans1
1 study
APOE
downin humans1
APOE is associated with memory in humans (β = -0.17, 95% CI -0.32 to -0.02).
“APOE ε4 carrier status was associated with lower memory ( β [95%CI]=‐0.17[‐0.32,‐0.02]) and visuospatial ( β [95%CI]=‐0.31[‐0.48, ‐0.14]) intercepts”
HumansAPOE ε4 carrier status in Korean (KBASE) cohort4-years of follow-upn = 245
The Differential Impact of APOE ε4 on Normative Cognitive Aging in Research Samples from the United States and Korea · AAIC 2025 abstract · 24 Dec 2025
Funding
National Institute on AgingUS$23.9mNational Institute of Allergy and Infectious DiseasesUS$139.6kEuropean Research Council€3m58 grants since 2021
National Institute on AgingUniversity of Massachusetts AmherstUS$547.3k2026–2031
National Institute on AgingNew York UniversityUS$786.7k2026–2031
Treatment of OSA on sleep-dependent memory and blood biomarkers in blacks
National Institute on AgingIcahn School of Medicine at Mount SinaiUS$1.7m2023–2028
Epigenetic and cellular mechanisms of age-related impairments in memory updating
National Institute on AgingPennsylvania State University, theUS$196.6k2026–2028
Investigating the epigenetic regulation of age-related memory decline
National Institute on AgingPrinceton UniversityUS$137.5k2026–2028
Pathway-Specific Vulnerability of Dopamine-Glutamate Neurons in Aging and Memory
National Institute on AgingAdvanced Science Research CenterUS$397.7k2026–2031
CXCL13 as an aging-associated defect in memory T cell homeostasis
National Institute of Allergy and Infectious DiseasesStanford UniversityUS$40.8k2024–2027
The role of sleep in protecting spatial memories from age-related decline
National Institute on AgingUniversity of California-irvineUS$221.9k2026–2028
National Institute on AgingColumbia University Health SciencesUS$50.1k2026–2028
National Institute on AgingTufts Medical CenterUS$889.7k2026–2031
Latest
1,332Protein deficiency impaired memory in aging mice
Experiments in 15-month-old mice with reduced Nipsnap1, a protein involved in cell maintenance, found reduced gene activity linked to nerve-cell…Experiments in 15-month-old mice with reduced Nipsnap1, a protein involved in cell maintenance, found reduced gene activity linked to nerve-cell signalling and increased activity linked to inflammation.
Brain thinning detected before dementia in people under 65
An observational study of 292 people under 65 linked two positive Alzheimer’s-related spinal-fluid tests to earlier and more extensive thinning.An observational study of 292 people under 65 linked two positive Alzheimer’s-related spinal-fluid tests to earlier and more extensive thinning.
Brain patterns linked to depression and markers of brain decline
An observational study of 353 adults aged 36–87 linked distinct brain patterns to later depression in younger women and blood markers of brain…An observational study of 353 adults aged 36–87 linked distinct brain patterns to later depression in younger women and blood markers of brain deterioration in older men.
Tetanus vaccine ingredient improved learning and memory in aging mice
An experiment in twelve-month-old mice found better learning and memory alongside more immature nerve cells and greater insulation around nerve…An experiment in twelve-month-old mice found better learning and memory alongside more immature nerve cells and greater insulation around nerve fibres.
Immigration arrest rates linked to poorer recall in Latinx adults
An observational study linked higher county immigration arrest rates to poorer recall among Latinx adults in early midlife, relative to White adults.An observational study linked higher county immigration arrest rates to poorer recall among Latinx adults in early midlife, relative to White adults.
Social isolation linked to poorer memory in young and older adults
An observational analysis of 18,553 people aged 11 and older across three US cohorts linked persistent isolation and loneliness to poorer memory…An observational analysis of 18,553 people aged 11 and older across three US cohorts linked persistent isolation and loneliness to poorer memory scores.