Critically short telomeres

1. Dasatinib + quercetin showed no clear effect on critically short telomeres in old mice, despite reduced telomere length.

   “yet this did not result in critically short telomeres and thus telomere dysfunction”

   Animalsin old mice, despite reduced telomere lengthlung

   Senolytics Reduce Endothelial Cell DNA Damage and Telomere Dysfunction Despite Reductions in Telomere Length

   Aging biology·Jun 27, 2023

More on Dasatinib + quercetin

1. Age is linked with higher critically short telomeres in healthy donors (0.32 ± 0.02%/year).

   “the percentage of chromosomes with CSTs increases with age at a rate of 0.32 ± 0.02%/year”

   Humansin healthy donorsperipheral blood lymphocytesn = 158

   High-Throughput Human Telomere Length Analysis at the Single-Chromosome Level by FISH Coupled with Nano-Flow Cytometry

   Analytical chemistry·Jul 1, 2021