CA1 volume

1. CA1 volume was not clearly linked with memory function in humans (healthy older adults) (estimate -0.14; 95% CI -0.37 - 0.10; p = 0.26).

   “cornu ammonis 1 subfield was not found to be associated with low declining cognition”

   Humanshealthy older adultshippocampus4-year periodn = 482

   Relationship between hippocampal subfield volumes and cognitive decline in healthy subjects

   Frontiers in aging neuroscience·Dec 7, 2023

1. FCSRT-IR recall is associated with CA1 volume in SCD and HC participants (r = 0.419, p = 0.017 (left); r = 0.412, p = 0.019 (right)).

   “Moderate associations of the FCSRT-IR LTR rate with CA1 bodies in both hemispheres (left CA1 body r = 0.419, p = 0.017; right: r = 0.412, p = 0.019)”

   Humansin SCD and HC participantshippocampusn = 32

   Long-term retrieval performance is associated with CA1 hippocampal volume in older adults and individuals at risk for dementia

   Alzheimer's research & therapy·Aug 22, 2025

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1. CA1 volume is associated with verbal memory performance in humans (without dementia).

   “The verbal free recall and verbal recognition performances were positively associated with CA1 and strata radiatum, lacunosum and moleculare volumes.”

   Humanswithout dementiahippocampusn = 97

   Hippocampal subfield associations with memory depend on stimulus modality and retrieval mode

   Brain communications·Nov 9, 2023

1. Amyloid-beta is associated with CA1 volume in cognitively unimpaired older adults (p<0.05).

   “significant Aβ status * age interaction were observed for CA1 (p<0.05), where volumes were negatively associated with age in the Aβ+ group only.”

   Humansin cognitively unimpaired older adultsCA1n = 130

   Effects of amyloid and APOE4 on medial temporal lobe subregions in cognitively unimpaired elderly

   medRxiv·Jan 22, 2022Preprint

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