Cognitive function
Biomarker7 papers
- Human trial1
- Humans4
Latest
79Daily activity patterns alter cognitive links to widowhood
In 4,427 older Chinese adults followed across three survey waves, lower cognitive function linked to widowhood occurred primarily in passive and…In 4,427 older Chinese adults followed across three survey waves, lower cognitive function linked to widowhood occurred primarily in passive and television-dominant sedentary activity patterns.
Silencing LCN2 eases postoperative cognitive deficits in mice
AAV-mediated knockdown of LCN2 in aged mice limited microglial inflammation, reduced neuronal pyroptosis, and rescued memory following surgery.AAV-mediated knockdown of LCN2 in aged mice limited microglial inflammation, reduced neuronal pyroptosis, and rescued memory following surgery.
Brainstem volume links to better memory in midlife
In 198 adults aged 40 to 65, larger brainstem volume tied to better memory, with the strongest link seen in participants with elevated arterial…In 198 adults aged 40 to 65, larger brainstem volume tied to better memory, with the strongest link seen in participants with elevated arterial stiffness.
Sarcopenia with metabolic syndrome links to cognitive decline
Their co-occurrence showed a 2.64-fold higher odds of persistently low cognition and 2.38-fold higher odds of rapid decline in 5,985 older adults.Their co-occurrence showed a 2.64-fold higher odds of persistently low cognition and 2.38-fold higher odds of rapid decline in 5,985 older adults.
Higher fitness links to lower cognitive impairment in frail adults
In prefrail and frail adults, top-quartile cardiorespiratory fitness was tied to lower odds of cognitive impairment (OR 0.15) versus the lowest…In prefrail and frail adults, top-quartile cardiorespiratory fitness was tied to lower odds of cognitive impairment (OR 0.15) versus the lowest quartile.
DNA methylation variability provides a distinct epigenetic marker of human aging heterogeneity
Combining methylation variance with mean methylation levels improved predictions of all-cause mortality across two independent human cohorts.Combining methylation variance with mean methylation levels improved predictions of all-cause mortality across two independent human cohorts.