Amyloid-beta plaques

1. Skeletal muscle-derived extracellular vesicles decrease amyloid-beta plaques in mice.

   “exercise-induced SKM-EVs induce polarization of disease-associated microglia and enhance the clearance of amyloid-beta plaques”

   Animalsin Alzheimer's disease mice

   Exercise alleviates cognitive dysfunction in Alzheimer's disease mice via skeletal muscle-derived extracellular vesicles that enhance plaque clearance by microglia

   Nature aging·2 Mar 2026

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1. Cadmium increases amyloid-beta plaques in mice.

   “Cd and Pb both can accelerate the pace of amyloid beta (Aβ) plaque formation and the decline of cognitive functions in 5xFAD mice.”

   Animals5xFAD micebrain0.002%6 weeks

   Cadmium exposure accelerates cognitive deficits and Alzheimer's disease progression in 5xFAD mice

   AAIC 2025 abstract·24 Dec 2025

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1. Haeepgp decreases amyloid-beta plaques in mice.

   “reduced the amount of Aβ plaques and behavioral decline in 5xFAD mice.”

   Animalsin 5xFAD mice

   HAEEPGP Peptide Efficiently Prevents Alzheimer's Disease Pathology in Vivo

   AAIC 2025 abstract·23 Dec 2025

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1. APP increases amyloid-beta plaques in mice.

   “Amyloid plaques are first detected in cortical regions at 4 months of age and accumulate up to about 12 months.”

   Animalscortex

   Characterization of the APP SAA mouse model for use in preclinical testing of Alzheimer's disease therapeutics

   AAIC 2025 abstract·24 Dec 2025

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1. PPT1 increases amyloid-beta plaques in mice.

   “Heterozygosity of PPT1 increases Ab plaques, insoluble Ab40 and Ab42 levels, and decreases the life span of 5xFAD mice.”

   Animalsin 5xFAD mice

   Heterozygosity of lysosomal enzyme genes and Alzheimer's disease

   AAIC 2025 abstract·23 Dec 2025

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1. Amyloid-beta plaques are associated with white matter injury in mice.

   “In models of demyelination and disease, we identified regions of enhanced oligodendrocyte resilience and vulnerability and white matter injury near β-amyloid plaques”

   Animalsbrain

   Brain-wide mapping of oligodendrocyte organization, oligodendrogenesis, and myelin injury

   Cell·18 Feb 2026

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1. Amyloid-beta plaques are associated with protein content in C. aethiops.

   “Neurons adjacent to plaques, as compared to those distant to plaques, also showed differential expression of some proteins.”

   Animalsparietal cortexn = 5

   Spatial molecular characterization of early Alzheimer's disease neuropathology in aged Vervet monkeys

   AAIC 2025 abstract·24 Dec 2025

1. Amyloid-beta plaques are associated with GFAP in C. aethiops.

   “Aβ plaques were associated with increased content of Ab‐42, Ab‐42, IBA1, GFAP, APP, and autophagy related proteins.”

   Animalspresence of Aβ plaquesparietal cortexn = 5

   Spatial molecular characterization of early Alzheimer's disease neuropathology in aged Vervet monkeys

   AAIC 2025 abstract·24 Dec 2025

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1. Amyloid-beta plaques are associated with IBA1 in C. aethiops.

   “Aβ plaques were associated with increased content of Ab‐42, Ab‐42, IBA1, GFAP, APP, and autophagy related proteins.”

   Animalspresence of Aβ plaquesparietal cortexn = 5

   Spatial molecular characterization of early Alzheimer's disease neuropathology in aged Vervet monkeys

   AAIC 2025 abstract·24 Dec 2025

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