Cadmium exposure accelerates cognitive deficits and Alzheimer's disease progression in 5xFAD mice

Abstract

Background: Epidemiological studies have identified an association between the exposure to neurotoxic heavy metals such as cadmium (Cd) and an increased risk for Alzheimer's disease (AD). However, the cellular and molecular mechanisms by which Cd or lead (Pb) exposure affects AD pathogenesis and progression are largely unknown.