The purinergic signaling in Alzheimer's disease: possible use of a shed form of the P2X7 receptor (sP2X7R) as a biomarker of early dementia

Abstract

Background: Neuroinflammation, one of the recognised factors in AD, is likely sustained by the presence of high amounts of extracellular ATP (eATP) in the inflammed brain. One main goal of our study was the measurement of eATP levels in the brain of an AD mice model using suitable luminescent probes produced in our laboratory.

The paper