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White matter injury

Disease

2 papers1 finding

  • Animals2

Associations

1

Amyloid-beta plaques

upin mice1

1 study

  1. Amyloid-beta plaques are associated with white matter injury in mice.

    “In models of demyelination and disease, we identified regions of enhanced oligodendrocyte resilience and vulnerability and white matter injury near β-amyloid plaques”

    Animalsbrain

    Brain-wide mapping of oligodendrocyte organization, oligodendrogenesis, and myelin injury

    Cell18 Feb 2026

More on Amyloid-beta plaques

Funding

1 grant since 2025

National Institute on AgingUS$1m

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Scientific Reports

A protein mutation curbs brain damage in mice with dementia

Young and 18-month-old mice with an altered UCHL1 protein showed less white matter injury and better sensorimotor and cognitive performance in a dementia model.Young and 18-month-old mice with an altered UCHL1 protein showed less white matter injury and better sensorimotor and cognitive performance in a dementia model.

Experiments in miceMechanisms
Paper

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