2 papers1 finding
Icariin
upin mice1
Icariin increases Akkermansia in mice (3.9-fold (p = 0.012)).
“males displayed Akkermansia amplification (3.9-fold, p = 0.012)”
Animals100 mg/kg/day15 daysmales
Sex-Dimorphic Gut Microbiota Modulation by Icariin in Older Mice
GSA 2025 abstract31 Dec 2025
Overfeeding young mice damaged gut microbes, impaired muscle cell energy production, and worsened age-related muscle wasting in later life.Overfeeding young mice damaged gut microbes, impaired muscle cell energy production, and worsened age-related muscle wasting in later life.
In 1,048 older adults, higher dietary inflammation scores were linked to greater odds of age-related muscle loss, with an odds ratio (a comparison of odds) of 1.305.In 1,048 older adults, higher dietary inflammation scores were linked to greater odds of age-related muscle loss, with an odds ratio (a comparison of odds) of 1.305.
In human lung cells that had stopped dividing, laboratory experiments found that acetate also reduced inflammatory responses.In human lung cells that had stopped dividing, laboratory experiments found that acetate also reduced inflammatory responses.
The treatment reduced oxidative stress, suppressed inflammation, and remodeled the gut microbiome in naturally aging mice while prolonging survival in nematodes.The treatment reduced oxidative stress, suppressed inflammation, and remodeled the gut microbiome in naturally aging mice while prolonging survival in nematodes.