2 papers1 finding
Biological sex
mixedin humans1
Biological sex is associated with age-associated DNA methylation in humans (16 sex-moderated aDMPs (0.002%) across tissues).
“Sex moderation was observed for only 16 aDMPs (0.002%), indicating that sex effects on age-associated DNA methylation are largely tissue-specific rather than shared across tissues.”
Humanssex moderation across tissueseight human tissuesmale and femalesn = 36,000
Tissue-specific divergence in sex-biased DNA methylation across the lifespan
bioRxiv (Cold Spring Harbor Laboratory)21 Apr 2026Preprint
An observational analysis of 126 whole-blood DNA profiles identified 409 genes with age-linked changes in chemical marks throughout life.An observational analysis of 126 whole-blood DNA profiles identified 409 genes with age-linked changes in chemical marks throughout life.
In Danish twins, adherence linked cross-sectionally to slower DunedinPACE, but within-pair and longitudinal analyses attenuated the associations over 12 years.In Danish twins, adherence linked cross-sectionally to slower DunedinPACE, but within-pair and longitudinal analyses attenuated the associations over 12 years.