Age-associated differentially methylated regions

Chronological age is associated with age-associated differentially methylated regions in humans (80 aDMRs (0.09% of analysed regions)).

“Age-associated changes at the regional level were less common, with only 80 robust age-associated aDMRs detected across tissues, representing 0.09% of analysed regions.”

Humanseight human tissuesmale and femalesn = 36,000

Tissue-specific divergence in sex-biased DNA methylation across the lifespan

bioRxiv (Cold Spring Harbor Laboratory)·21 Apr 2026Preprint