Aβ accumulation

2 papers2 findings

Humans1
Animals1

Interventions

1

Nicotinamide mononucleotide

downin mice1

1 study

Nicotinamide mononucleotide decreases Aβ accumulation in mice.
“NMN supplementation also enhanced ATP production, mitochondrial function, and synaptic density in the hippocampus while reducing oxidative stress and Aβ accumulation in the brain.”
AnimalsAPP/PS1 transgenic Alzheimer's disease modelbrain
Nicotinamide mononucleotide supplementation modulates gut microbiota and metabolites to mitigate Alzheimer's disease pathology in APP/PS1 mice
Journal of Alzheimer's disease : JAD10 Mar 2026

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Associations

1

Aβ42/Aβ40

downin humans1

1 study

Aβ42/Aβ40 is associated with Aβ accumulation in humans (b=-142.29, p=0.002).
“plasma Aβ42/40 was significantly associated with Aβ accumulation (ADNI: b=‐142.29, p = 0.002; UPitt: b=‐0.27, p = 0.02)”
HumansPET A- non-demented participants
Utilization of plasma Aβ and p ‐tau217 in predicting Aβ accumulation in PET A‐ non‐demented participants
AAIC 2025 abstract11 Jan 2026

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