ABCA1

1. Type 2 diabetes decreases ABCA1 in humans.

   “Circulatory ABCA1 and ABCG1 levels were significantly lower in T2DM+A and T2DM than in NGT group”

   Humansin T2DM and T2DM with atherosclerosis

   ABC Transporters as Surrogate Biomarkers of HDL Functionality for Early Atherosclerosis Risk Assessment in Type 2 Diabetes Mellitus

   ADA Scientific Sessions 2026 abstract·Jun 6, 2026

More on Type 2 diabetes

1. ABCA1 predicts atherosclerosis in humans (AUC 0.782, 95% CI 0.684-0.861).

   “ROC curve analysis for ABCA1 yielded an AUC of 0.782 (95% CI: 0.684-0.861; Cutoff 0.5086 ng/mL)”

   Humansdiscriminating atherosclerosis risk/groups

   ABC Transporters as Surrogate Biomarkers of HDL Functionality for Early Atherosclerosis Risk Assessment in Type 2 Diabetes Mellitus

   ADA Scientific Sessions 2026 abstract·Jun 6, 2026

More on Atherosclerosis

1. ABCA1 is associated with cholesterol efflux in humans.

   “HDL functionality as measured by CE was significantly reduced in patients with T2DM+A and T2DM, and positively associated with ABC transporters.”

   Humansin T2DM and NGT subjects

   ABC Transporters as Surrogate Biomarkers of HDL Functionality for Early Atherosclerosis Risk Assessment in Type 2 Diabetes Mellitus

   ADA Scientific Sessions 2026 abstract·Jun 6, 2026

More on Cholesterol efflux

1. ABCA1 is associated with P-TAU181 in humans.

   “Both proteins positively correlated with phospho-Tau (181), a classical hallmark of DAT.”

   Humansplasma

   Dysregulation of Lipid Metabolism Serves as A Link Between Alzheimer's and Cardiovascular Disease, As Witnessed in A Cross-Sectional Study

   Aging and disease·May 31, 2024

More on P-TAU181

1. Cardiovascular disease is associated with ABCA1 in humans.

   “Finally, the differential expression of ABCA1 and APOH proteins was verified, in an independent cohort also including controls and patients with CVD alone.”

   Humansin an independent cohort including controls, DAT, and CVD patientsplasma

   Dysregulation of Lipid Metabolism Serves as A Link Between Alzheimer's and Cardiovascular Disease, As Witnessed in A Cross-Sectional Study

   Aging and disease·May 31, 2024

More on Cardiovascular disease