APOH

1. APOH increases triglyceride secretion in human cells (p < 0.05).

   “Finally, siRNA silencing of APOH in human Huh7 cells led to reduced TG secretion (two-sample t-test, p < 0.05).”

   Cellsshown by knockdownhepatocytes

   APOH plays a distinct role in lipid trait dysregulation and increased CVD risk

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

1. APOH decreases triglyceride in silico (p < 5 x 10 −8).

   “Mendelian randomization analysis suggested that genetically determined lower ApoH plasma levels causally decrease plasma TG levels (p < 5 x 10 −8 ).”

   In silicoMendelian randomization

   APOH plays a distinct role in lipid trait dysregulation and increased CVD risk

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

More on Triglyceride

1. APOH is associated with low-density lipoprotein cholesterol in humans (p < 0.01).

   “APOH C325G was associated with lower triglyceride (TG) levels and higher LDL-C, apoB, and Lp(a) levels (p < 0.01).”

   Humanslaboratory analysis

   APOH plays a distinct role in lipid trait dysregulation and increased CVD risk

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

More on Low-density lipoprotein cholesterol

1. APOH is associated with triglyceride in humans (p < 0.01).

   “APOH C325G was associated with lower triglyceride (TG) levels and higher LDL-C, apoB, and Lp(a) levels (p < 0.01).”

   HumansPheWAS and laboratory analysis

   APOH plays a distinct role in lipid trait dysregulation and increased CVD risk

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

More on Triglyceride