Transient reprogramming has been studied in 7 papers since 2020: 1 observational study in people, 4 in animals, 1 in cells; 4 in the past year. The newest story, Oct 10, 2026: “Short reprogramming reverses blood stem cell aging in mice”.
InterventionPartial reprogramming
7 papers study it13 findingsUpdated
1 new paper in 30 daysSee all 7
None of its findings points the other way.
Mouse preprints report improved hematopoietic reconstitution, reproduced by independent labs, alongside reduced chromatin accessibility at AP-1-bound regions in hematopoietic stem cells and reduced myeloid bias during physiological and LPS-driven stem-cell aging. The work spans two independent labs in one country; two of four findings have an author at Inovarion.
13 findings in 6 papers from 2020 to 2026, 3 of them since June 2026
Studies of Transient reprogramming measured 12 outcomes; the most studied are hematopoietic reconstitution (2 studies), premature hematopoietic stem cell aging (1) and chromatin accessibility at AP-1-bound regions (1).
Hematopoietic reconstitution
upin mice2
Transient reprogramming improves hematopoietic reconstitution in mice.
“while in old mice it reverses HSC aging features, improving hematopoietic reconstitution, reducing myeloid bias and DNA damage.”
AnimalsYamanaka factor inductionhematopoietic stem cell16 days
Short reprogramming reverses blood stem cell aging in mice
Research SquarePreprint
Transient reprogramming improves hematopoietic reconstitution in mice.
“Transient reprogramming improved hematopoietic reconstitution, reduced myeloid bias, and limited DNA damage.”
Animalsphysiological and LPS-driven HSC aging
bioRxivPreprint
Premature hematopoietic stem cell aging
downin mice1
Transient reprogramming protects against premature hematopoietic stem cell aging in mice.
“Reprogramming protected HSCs from chronic LPS-induced premature aging.”
Animalschronic lipopolysaccharide exposurehematopoietic stem cell
Short reprogramming reverses blood stem cell aging in mice
Research SquarePreprint
Chromatin accessibility at AP-1-bound regions
downin mice1
Transient reprogramming decreases chromatin accessibility at AP-1-bound regions in mice.
“reprogramming induces an early reduction in chromatin accessibility at AP-1-bound regions”
Animalshematopoietic stem cell
Short reprogramming reverses blood stem cell aging in mice
Research SquarePreprint
DNA damage
downin mice1
Transient reprogramming decreases DNA damage in mice.
“while in old mice it reverses HSC aging features, improving hematopoietic reconstitution, reducing myeloid bias and DNA damage.”
AnimalsYamanaka factor inductionhematopoietic stem cell16 days
Short reprogramming reverses blood stem cell aging in mice
Research SquarePreprint
Myeloid bias
downin mice1
Transient reprogramming decreases myeloid bias in mice.
“Transient reprogramming improved hematopoietic reconstitution, reduced myeloid bias, and limited DNA damage.”
Animalsphysiological and LPS-driven HSC aging
bioRxivPreprint
Blood flow
upin mice1
Transient reprogramming increases blood flow in mice.
“a significantly improved blood flow was observed at 7 and 14 days after hind-limb ischemia in 21 months old C57BL/6 mice (p < 0.001).”
Animalshind-limb ischemia7 and 14 days
Functional rejuvenation of endothelial cell aging by transient reprogramming
Basic research in cardiology
Integrated proviral DNA
downin human cells1
Transient reprogramming decreases integrated proviral DNA in human cells.
“transient reprogramming of patient-derived CD4+ T cells restores their ability to eliminate HIV-infected reservoirs, excising integrated proviral DNA”
Cellsex vivo treatment of patient-derived CD4+ T cells
Awakening intracellular immunity for functional HIV cure
bioRxiv (Cold Spring Harbor Laboratory)Preprint
Retroelement epigenetic clock
downin silico1
Transient reprogramming decreases retroelement epigenetic clock in silico.
“retroelement epigenetic clocks were reversed during transient epigenetic reprogramming”
In silicotransient epigenetic reprogramming
bioRxiv : the preprint server for biologyPreprint
Lifespan
upin mice1
Transient reprogramming extends lifespan in mice.
“transient reprogramming can ameliorate age-associated hallmarks and extend lifespan in progeroid mice”
Reviewprogeroid mice
Nature communications
Stem cell maintenance
upin human cells1
Transient reprogramming improves stem cell maintenance in human cells.
“restoration of youthful regenerative response to aged, human muscle stem cells”
Cellsnaturally aged human cellsmuscle stem cell
Nature communications
Japan Society for the Promotion of ScienceJP¥4.4mNederlandse Organisatie voor Wetenschappelijk Onderzoek
Activating reprogramming factors for 16 days in old mice reduced DNA damage, improved blood reconstitution, and dampened transposable element activity.Activating reprogramming factors for 16 days in old mice reduced DNA damage, improved blood reconstitution, and dampened transposable element activity.