Traffic-related air pollution

4 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: National Institute on Aging and 1 more

Humans3

Associations

Alzheimer's disease

upin humans2RR 2.64–2.77

2 studies

Traffic-related air pollution raises the risk of Alzheimer's disease in humans (+164%, RR 2.64, 95% CI 1.79-3.88).
“UKB participants with a history of infections and exposure to TRAP had a 164% higher risk of AD+ (RR=2.64, 95% CI [1.79; 3.88], men and women combined)”
Humanshistory of infections
Traffic‐related air pollution significantly aggravates the detrimental impact of infections on the risk of Alzheimer's disease, particularly in non‐carriers of APOE4
AAIC 2025 abstract23 Dec 2025
Traffic-related air pollution raises the risk of Alzheimer's disease in humans (RR=2.77, 95% CI [1.86, 4.11]).
“presence of both, a history of infections and exposure to TRAP in UKB participants aged 60-75, was associated with 177% higher risk of AD onset after the age of 75”
Humanshistory of infections and exposure to TRAP
TRAFFIC-RELATED AIR POLLUTION AND INFECTIONS JOINTLY INCREASE THE RISK OF ALZHEIMER’S DISEASE IN OLDER ADULTS
GSA 2024 abstract31 Dec 2024