Traffic‐related air pollution significantly aggravates the detrimental impact of infections on the risk of Alzheimer's disease, particularly in non‐carriers of APOE4

Abstract

Background: Alzheimer's disease (AD) likely results from a combination of genetic, environmental, and other factors. Accumulating evidence points to a role of infections in AD. Traffic‐related air pollution (TRAP) and APOE4 are major risk factors for AD that may act together with infections to influence AD risk.