Thyroxine
- 1 lab in 1 country
- Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico and 1 more
- Animals1
Outcomes
3Muscle atrophy
upin mice1
1 study
Muscle atrophy
upin mice1
Thyroxine induces muscle atrophy in mice.
“Rather than improving regeneration, T4 replacement therapy appears to induce atrophy and tissue remodeling.”
Animals7 days after injury by 1.2% BaCl2 injectiontibial anterior7.5 ng/g body weightmales
Thyroxine does not improve skeletal muscle regeneration after injury in aged mice
The Journal of endocrinology25 Nov 2025
Muscle fiber cross-sectional area
downin mice1
1 study
Muscle fiber cross-sectional area
downin mice1
Thyroxine decreases muscle fiber cross-sectional area in mice.
“we observed a decrease in cross-sectional area and an increase in myonuclei domain, cell death, and laminin expression in T4-treatment injured muscles.”
Animals7 days after injury by 1.2% BaCl2 injectiontibial anterior7.5 ng/g body weightmales
Thyroxine does not improve skeletal muscle regeneration after injury in aged mice
The Journal of endocrinology25 Nov 2025
Central nuclei
downin mice1
1 study
Central nuclei
downin mice1
Thyroxine decreases central nuclei in mice.
“T4 treatment decreases the number of central nuclei, indicative of newly formed fibers.”
Animals7 days after injury by 1.2% BaCl2 injectiontibial anterior7.5 ng/g body weightmales
Thyroxine does not improve skeletal muscle regeneration after injury in aged mice
The Journal of endocrinology25 Nov 2025