Subclinical hypothyroidism

Disease2 papers5 findings

In one mouse study under AR-SCH conditions, subclinical hypothyroidism reduces functional proteins and protein phosphorylation in the thyroid and is associated with thyroid extracellular matrix remodelling.

Animals1

Effects

Protein phosphorylation

downin mice1−92% downregulated sites

1 study

Subclinical hypothyroidism decreases protein phosphorylation in mice (91.53% downregulated sites).
AnimalsAR-SCH conditionsthyroid
Integrated multi-omics atlas reveals PTM-driven signaling and immunologic remodeling in a mouse model of age-related subclinical hypothyroidism · American journal of translational research · 15 Aug 2026

Protein phosphorylation →

Functional proteins

downin mice1−82% downregulated

1 study

Subclinical hypothyroidism decreases functional proteins in mice (81.7% downregulated).
AnimalsAR-SCH conditionsthyroid
Integrated multi-omics atlas reveals PTM-driven signaling and immunologic remodeling in a mouse model of age-related subclinical hypothyroidism · American journal of translational research · 15 Aug 2026

Functional proteins →

Chronic kidney disease

no changein humans1OR 0.96

1 study

Subclinical hypothyroidism has no effect on chronic kidney disease in humans (adjusted OR 0.96, 95% CI 0.39-2.38).
Humanswithout hypertension
Association Between Chronic Kidney Disease and Subclinical Hypothyroidism Categorized by Hypertension Status · Diseases (Basel, Switzerland) · 6 Aug 2026

Chronic kidney disease →

Associations

Extracellular matrix remodelling

downin mice1

1 study

Subclinical hypothyroidism is associated with extracellular matrix remodelling in mice.
AnimalsAR-SCHthyroid
Integrated multi-omics atlas reveals PTM-driven signaling and immunologic remodeling in a mouse model of age-related subclinical hypothyroidism · American journal of translational research · 15 Aug 2026

Extracellular matrix remodelling →

Chronic kidney disease

upin humans1OR 2.76

1 study

Subclinical hypothyroidism is associated with chronic kidney disease in humans (adjusted OR 2.76, 95% CI 1.37-5.59).
Humanswith hypertension
Association Between Chronic Kidney Disease and Subclinical Hypothyroidism Categorized by Hypertension Status · Diseases (Basel, Switzerland) · 6 Aug 2026

Chronic kidney disease →